摘要
目的 研究细胞核增殖抗原 Ki- 6 7在人脑胶质瘤中的表达强度与病理分级的关系 ,比较 Ki- 6 7与其他评价肿瘤增殖潜能指标的优越性。方法 SP免疫组化方法对 41例不同级别人脑胶质瘤细胞的 Ki- 6 7表达进行观察 ,评价染色强度和阳性细胞百分数与胶质瘤细胞恶性度的关系。结果 全部受检病例中对照组 Ki- 6 7均为阴性染色 ,全部胶质瘤标本表达阳性率达 85 %星形细胞瘤 级绝大部分病例为阴性染色 ,只存在 2例阳性染色。结论 Ki- 6 7表达与胶质瘤恶性程度相关 ,其表达水平不仅可以反映胶质瘤的恶性增殖潜能 ,亦可反映其预后 ,Ki- 6 7在人脑胶质瘤中的表达可以应用于临床 ,作为评价胶质瘤生物学行为、选择治疗措施。
Objective To research on the relationship between the expressional intensity of PCNA Ki 67 and the pathological grade in human brain glioma. To compare the superiority of Ki 67 as a marker of tumor proliferation protential over other ones. Methods A SP immunohistochemical staining technique was undertaken to detect the expression of Ki 67 in 41 cases of glioma with various patholotical grades. To evaluate the relationship between the dying strenth, percentage of positive celles and the degree of glioma. Results There were the results of all the 41 examinated cases. In the control group all were Ki 67 negative. As far as gliomas were concerned, the positive rate was 85%. When it came to astrocytomas of gradeⅠ, there were only 2 Ki 67 positive outcomes and that means all the left ones were negative. Conclusion There is relationship between the expression of Ki 67 can reflect the degree of glioma and it is prognosis as well. The research of Ki 67 expression in glioma can be applied as a cogent measurement clinically to evaluate the bioactivity of tumors, to choose treatment stratedy, to predict patients existance span.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2001年第2期81-83,共3页
Journal of Apoplexy and Nervous Diseases
