摘要
目的:探讨P27蛋白表达与头颈部鳞癌的关系。方法:应用SP免疫组化方法对52例头颈部鳞癌和20例声带息肉组织进行检测。结果:P27蛋白在声带息肉组织的表达阳性率为100%(20/20),在头颈部鳞癌组织中阳性率为67.3%(35/52),二者差异有显著性(P<0.05)。P27蛋白表达与头颈部鳞癌患者的年龄无明显相关,而与组织分化程度显著相关,高分化、中分化头颈部鳞癌P27蛋白表达阳性率明显比低分化高(P<0.01)。结论:P27蛋白在头颈部鳞癌的发生发展中起一定作用,并可作为判断头颈部鳞癌恶性度的重要指标。
Objective：To study the relationship between the expression of P27 in head and neck squamous cell Carcinoma. Method： Expression of P27 protein in 52 eases of head and neck squamnus cell carcinomas and 20 cases of polyps of vocal cord were investigated with immunohistochemical SP. Results： The positive rate of P27 protein expression was 100%（20/20） in polyps of vocal cord and was 67.3%（35/52） in squamous cell carcinomas. The difference was significant （x^2=4.6342,P〈0.05）. The expression of P27 protein did not correlate with age, but correlated significantly with histological grading. A significantly higher poshive rate of P27protein was found in well or moderately differentiated sqnamous cell than in poorly differentiated tumor （x62=7.4806,P〈0.01）. Conclusions： P27 protein may play an important role in the proc.ess of eareinogenesis of squamous cell carcinomas.
出处
《大理学院学报（综合版）》
CAS
2007年第12期19-20,共2页
Journal of Dali University
基金
云南省卫生厅科研基金资助项目(99M003)
关键词
鳞癌
P27蛋白
免疫组化
P27 protein
squamous cell carcinomas
immunohistoehemieal
