摘要
目的探讨芬太尼对兔定量药物脑电图(QPEEG)β2频段功率的影响及其与阿片受体的关系。方法 36只家兔,分6组(n=6):NS组(生理盐水1 ml.kg-1)、NA组(纳洛酮200μg·kg-1)、LD组(芬太尼10μg·kg-1)、MD组(芬太尼20μg·kg-1)、HD组(芬太尼40μg·kg-1)和NAF组(纳洛酮200μg·kg-1+芬太尼40μg·kg-1),应用QPEEG,采用功率谱分析法,观察兔给药前后β2频段百分比的变化。结果与给药前相比,NS组、LD组和NA组β2频段功率百分比无明显变化(P>0.05);MD组和HD组中β2频段功率百分比在大部分脑区增加(P<0.05,P<0.01),此改变与芬太尼剂量呈正相关。除少数时点、个别脑区外,NAF组β2频段功率百分比均与给药前相似(P>0.05)。结论芬太尼以剂量依赖方式增加兔QPEEGβ2频段功率百分比,纳洛酮可拮抗此作用,表明阿片受体介导了这一过程,提示β2功率百分比可能作为反映镇痛程度的监测指标。
Aim To investigate the effects of fentanyl on [32-band of quantitative pharmaco-elcctroencephalography of rabbits and its relationship with the opioid receptor. Methods Thirty-six healthy rabbits were divided randomly into 6 groups： NS （1μg·kg-1 Baanced Saline）,NA（200 μg·kg-1 naloxone）,LD（ 10μg·kg-1 fentanyl） , MD （ 20 μg·kg-1 fentanyl）, HD （ 40 μg·kg-1 fentanyl ） andNAF （ 200 μg·kg-1 naloxone and 40 μg·kg-1 fentanyl）. Power spectral analysis was used to check the changes of the percentage of β2-band power before and after the intravenous injections of fentanyl and naloxone. Results Compared with the baseline, β2-band power percentage had no obvious difference （ P 〉 0. 05 ） between the groups of NS,LD and NA. In the groups of MD and HD, β2- band power percentage significantly increased in most encephalic regions （ P 〈 0. 05 or P 〈 0. 01 ）, and the increases were positively correlated with the dose of fentanyl. In the NAF group, β2-band power percentage was similar to that before the administration except for some time-points and a few brain regions （ P 〉 0. 05 ）. Conclusion Fentanyl dose-dependently increases the percentage of β2-band power, while naloxone antagonizes the effect of fentanyl. The data suggest that opioid receptor mediates the process and the percentage of β2- band power may be an observed index monitoring the degree of analgesia.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2013年第8期1128-1132,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 30872432
30471657
39970715)
江苏省社会发展科技计划项目(No BS200054)
徐州医学院药学院研究生科研创新计划项目(No 2010YKYCX011)
关键词
芬太尼
纳洛酮
阿片受体
镇痛程度
定量药物脑电图
β2频段
fentanyl
naloxone
opioid receptor
anal- gesia degree
quantitative pharmaco-electroencephalogram
β2 rhythm.
