摘要
目的探讨局部麻醉手术中右美托咪定镇静下患者定量脑电图(quantitative pharmaco-electroencephalography,QPEEG)δ及α1波频率的变化。方法择期行局部麻醉手术患者40例,随机分为观察组和对照组,每组20例,观察组患者经鼻给予右美托咪定1μg/kg,对照组患者经鼻给予等量生理盐水。记录2组患者安静状态下(T0)、给药后20min(T1)和60min(T2)的脑电图,计算QPEEG的δ和α1波频率。结果观察组T2时左额区、右额区、左颞区、右颞区δ波频率[(8.72±0.58)、(8.52±0.68)、(8.61±0.84)、(8.59±0.79)Hz]明显高于T0时[(7.10±1.90)、(7.25±2.75)、(7.36±2.86)、(7.28±1.71)Hz]和T1时[(8.05±2.45)、(8.11±2.60)、(8.10±2.77)、(7.81±1.93)Hz],α1波频率[(7.92±1.78)、(8.22±1.65)、(8.52±2.14)、(8.59±1.75)Hz]明显低于T0时[(11.84±1.75)、(11.25±1.64)、(12.06±2.16)、(11.48±1.74)Hz]和T1时[(11.21±1.31)、(10.11±2.13)、(10.61±1.25)、(10.81±1.53)Hz](P<0.05),T1时与T0时比较差异无统计学意义(P>0.05);对照组患者T0、T1、T2时左额区、右额区、左颞区、右颞区δ、α1波频率比较差异均无统计学意义(P>0.05);观察组T2时左额区、右额区、左颞区、右颞区δ波频率高于对照组[(8.12±0.54)、(7.89±0.59)、(7.97±0.69)、(7.94±0.84)Hz],α1波频率明显低于对照组[(11.74±1.64)、(10.89±1.27)、(10.97±2.65)、(11.94±1.82)Hz](P<0.05),T0和T1时与对照组比较差异无统计学意义(P>0.05)。结论经鼻滴入右美托咪定后,局部麻醉手术患者定量脑电图δ波波动增加,α1波波动减少,δ和α1波频率变化可反映右美托咪定的镇静效果。
Objective To observe the changes of δ- and α1-band of quantitative pharmaco-electroencephalography （QPEEG） under dexmedetomidine sedation in local anesthesia. Methods Forty patients receiving selective operation under local anesthesia were randomly divided into observation group and control group, with 20 patients in each group. Observation group received nasal dexmedetomidine 1 μg/kg, and control group was given the equivalent volume of normal saline. The electroencephalography changes at the time points of quiet state （T0）, 20 min after administration （T1） and 60 min after the administration （T2） were recorded and the frequencies of the δ- and α1-band of QPEEG were calculated. Results In observation group, the frequencies of δ-band on the left and right frontal area, and left and right temporal area at T2（（8. 72±0.58）, （8.52±0.68）, （8.61±0.84）, （8.59±0.79） Hz） were significantly higher than those at T0 （（7.10±1.90）, （7.25±2.75）, （7.36±2.86）, （7. 28±1.71） Hz） and T1（（8. 05±2. 45）, （8. 11±2.60）, （8. 10±2.77）, （7.81±1.93） Hz）, the frequencies of α1-band were significantly lower at T2（（7. 92±1.78）, （8. 22±1. 65）, （8.52±2.14）, （8.59±1.75） Hz） than those at T0（（11. 84±1.75）, （11.25±1.64）, （12.06±2.16）, （11.48±1.74） Hz） and T1（（11. 21±1.31）, （10. 11±2. 13）, （10.61±1.25）, （10.81±1. 53） Hz） （P〈0.05）, and there were no significant differences between To and T1 （P〉0.05）. In control group, the frequencies of δ- and α1-band at To, T1 and T2 showed no significant differences in the left and right frontal area, and left and right temporal area （P〈0.05）. The frequencies of δ-band on the left and right frontal area, and left and right temporal area at T2 in observation group were significantly higher than those in control group （（8.12±0.54）, （7. 89±0.59）, （7.97±0.69）, （7.94±0.84） Hz）, the frequencies of α1-band on the left and right frontal area, and left and right temporal area in observation group were significantly lower than those in control group （ （11.74±1.64）, （ 10.89±1.27） , （ 10.97±2.65）, （ 11.94±1.82 ） Hz） （P〈0.05）, and there were no significant differences between To and T1 （P〉0.05）. Conclusion The increase of δ-band and the decrease of α1-band after nasal dexmedetomidine could reflect the sedative effect of dexmedetomidine.
出处
《中华实用诊断与治疗杂志》
2018年第2期182-184,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(81401231)
关键词
右美托咪定
定量脑电图
Δ频段
α1频段
Dexmedetomidine
quantitative pharmaco-electroencephalograph
δ-band
α1-band
