摘要
目的探讨胃肠道间质瘤的临床表现、病理组织形态学和免疫组织化学特点及良恶性参考指标。方法对34例胃肠道间质瘤患者的手术标本采用免疫组化PV-9000法进行CD117、CD34、S-100、SMA、Des、Ki-67标记、分析。结果 34例胃肠道间质瘤免疫组化CD117阳性率95%,CD34阳性率70%,S-100、SMA、Des局灶弱阳性或阴性表达,Ki-67表达不一。临床表现为腹部不适、腹痛、腹胀、上消化道出血及腹部包块。结论胃肠道间质瘤多发于中老年,肿瘤细胞形态多样,结构多样,免疫组化CD117和CD34阳性表达是确诊胃肠道间质瘤最有诊断价值的依据,但胃肠道间质瘤良、恶性诊断须结合肿瘤大体、组织学形态及生物学行为等综合考虑。
Objective To investigate the clinical manifestations and histopathological and immunohistochemical features of gastrointestinal stromal tumors, and to explore the index for the differentiation of benign and malignant tumors. Methods The expression of CDll7, CD34, S-100, SMA,Des, and Ki-67 was detected by immunohistochemistry （PV-9000 method）in surgical specimens from 34 patients with gastrointestinal stromal tumors. Results Among the 34 cases, the positive rates of CDll7, CD34 were 95%, 70%, respectively. Gastrointestinal stromal tumors were focal weak positive or negative for S-100, SMA and Des and exhibited different Ki-67 expression. The clinical manifestations of gastrointestinal stromal tumors included abdominal discomfort, abdominal distension, abdominal pain, upper gastrointestinal bleeding and abdominal mass. Conclusion Gastrointestinal stromal tumors occur mainly in the elderly with morphologically and structurally diverse tumor cells. The positive expression of CDll7 and CD34 is valuable in the diagnosis of gastrointestinal stromal tumor. However, the observation of gross morphology, histologic characteristics and biological behavior should be required for the differential diagnosis of benign and malignant gastrointestinal stromal tumors.
出处
《实用临床医学（江西）》
CAS
2013年第3期7-9,F0003,共4页
Practical Clinical Medicine
关键词
胃肠道间质瘤
病理诊断
病理分级
gastrointestinal stromal tumors
pathological diagnosis
pathological grading
