摘要
目的探讨胃肠道间质瘤(GIST)临床病理、免疫组织化学特征及预后特点。方法对58例手术切除的胃肠道间质瘤复习其临床特点及病理形态,运用CD117、CD34、PDGFR-α等抗体进行免疫组织化学分析,并随访35例。结果GIST58例中,发生于胃部35例,小肠10例,结肠5例,肠系膜3例,网膜2例,食管2例,直肠1例。主要症状有腹胀、腹痛、腹部包块、便血。镜下观察:分梭形细胞型,上皮细胞型,混合细胞型。免疫组化:CD117标记91%(53/58)阳性,CD34标记68.9%(40/58)阳性,PDGFR-α60.3%(35/58)。随访35例,良性10例,1例复发;恶性潜能未定9例,2例复发;恶性16例,4例复发,4例死亡。结论胃肠道间质瘤好发于中老年人,组织形态多变,结构多样。CD117联合CD34、PDGFR-α等有诊断及鉴别诊断作用,预后与组织学分级有关。
Objective To ingestive the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors（GIST） and to evaluate the prognostic significance in these tumors.Methods Fifty-eight cases of gastrointestinal stromal turmors were studied by histological evaluation alone with an immunohistochemistry panel including CD117,CD34,PDGFR-α,35 cases were followed-up.Results Among 58 GISTs,35 arose principally from the stomach,10 from the small intestine,and the others from the retroperitoneum,mesenterium,omentum,and esophagus.The important sympoms were vague pain,abdomen mass,abdominal pain and GI bleeding.Histologically,spindle cell type,epithelioid cell type and mixed cell type.Fifty-three cases of GISTs were positive for CD117,40 cases of GISTs also positive for CD 34 and 40 cases of GISTs also positive for PDGFR-α.Follow-up of 10 cases benign tumors found 1 case developed recurrence,and 9 cases bordline tumors,2 cases developed recurrence.In the malignant group of 16 cases,4 cases developed recurrence,4 cases died of tumor.Conclusion GISTs predominantly occurred in middle aged or old patients,and had varied cell types and different arrangements.CD117,CD 34 and PDGFR-α staining can be used in diagnosis and differential diagnosis.
出处
《临床医学》
CAS
2010年第3期1-3,共3页
Clinical Medicine
关键词
胃肠道间质瘤
临床病理
免疫组织化学
鉴别诊断
预后
GIST
Clinicopathological
Immunohistochemistry
Differential diagnosis
Prognostic
