摘要
目的探讨宫颈小细胞癌(SCCC)临床病理特点、诊断、治疗和预后。方法回顾性分析2005年1月至2009年10月在北京大学人民医院收治的6例SCCC患者的临床资料,分析临床病理特征及预后。结果6例患者中5例为初次收治的患者,均经手术治疗及术后放/化疗;其中3例术前行新辅助化疗后手术,1例为外院手术后2个月出现盆腔包块而转入北京大学人民医院化疗。另1例仅行2个疗程化疗后放弃治疗,3个月后死亡。全部患者均经病理检查,其中5例经免疫组化确诊。淋巴结转移率为80%(4/5)。患者中3/6例死亡,生存期分别为17、13、3个月。3例仍在治疗随访中,时间分别为8、6、1个月。结论SCCC恶性度高,预后差,死亡率高。其确诊主要依靠病理组织形态学和免疫组化。目前多采用手术、化疗和放疗联合综合治疗。
Objective To study the clinicopathological characteristics, diagnosis, treatment and prognosis of small cell cervical carcinoma（SCCC）. Methods Data of 6 cases with SCCC from January 2005 to October 2009 were analyzed retrospectively. Results Among the 6 cases pathologically diagnosed, 5 were immunohistochemically confirmed. 5 cases were admitted without pre-treatment, within which 3 cases underwent neoadjuvant chemotherapy, then received surgery and postoperative chemotherapy and radiation; 1 early stage case underwent surgery directly, then received postoperative chemotherapy and radiation; 1 case gave up treatment due to side effects of chemotherapy. Another case presented with pelvic mass after surgery in another hospital. She received chemotherapy in our hospital but didn＇t complete the whole cycles. 5 patients underwent surgery within which 4 cases （80%） had lymph node involvement confirmed.3 cases died with the survival time of 17,13 and 3 months, respectively.3 cases are still under treatment with follow-up of 8,6 and 1 month, respectively.Conclusions SCCC is an infrequently occurring tumor of high malignancy, with a poor prognosis and high mortality. Immunohistochemical and pathologic detection were the main methods to diagnose SCCC. Combined therapy including preoperative chemotherapy/radiation, surgical treatment and postoperative chemotherapy/radiation is suggested for the disease.
出处
《中国妇产科临床杂志》
2010年第2期101-104,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
宫颈肿瘤
小细胞癌
综合治疗
免疫组化
cervical carcinoma
small cell carcinoma
combined therapy
immunohistochemical
