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宫颈癌前病变中高危型HPV病毒负荷的临床分析 被引量:9

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摘要 目的:探讨宫颈癌前病变中检测高危型HPV病毒负荷的意义。方法:将2011年1月~2012年6月就诊的268例患者根据阴道镜下子宫颈病理结果分为正常组、CINⅠ组、CINⅡ组、CINⅢ组。采用美国Digene公司第二代基因杂交捕获信号放大检测试验,检测所有患者的HPV病毒含量,比较各组HR-HPV DNA阳性率及其在中度、低度、高度的分布比例,分析宫颈癌前病变与HPV病毒量的关系。结果:正常组、CIN-I组、CIN-II组、CIN-III组的HPV DNA阳性率分别为32.16%、53.19%、78.57%、87.5%;正常组在低度的分布比例显著低于CIN各组,而CIN各组在中高度的分布比例显著高于正常组,且差异均具统计学意义(P<0.05)。结论:高危型HPV负荷量与宫颈癌前病变的发生发展有明显的相关性,具有较高的筛查和诊治意义。
作者 杜玲
出处 《中国妇幼保健》 CAS 北大核心 2013年第4期611-612,共2页 Maternal and Child Health Care of China
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