摘要
目的探讨桥小脑角不典型脉络丛乳头状瘤的临床特点、病理诊断及鉴别诊断。方法对2例不典型脉络丛乳头状瘤的影像学、组织病理学和免疫组化特征进行研究,结合文献讨论其临床病理特征及鉴别诊断。结果本文病例均病理形态多样,部分区域分化差,细胞密度增加、核分裂3～5个/10 HPF,呈片状方式生长。免疫组化结果:CK、Vimentin、S-100呈阳性,Syn呈弱阳性;其他标记物如EMA、GFAP、CEA均呈阴性,Ki-67阳性率局部>5%。结论患者年龄、肿瘤准确定位等临床资料对病理诊断较为重要;严格掌握肿瘤的诊断标准并辅以合理的免疫组化检查,对诊断与鉴别诊断极为重要。
Objective To study the clinical features,pathological diagnosis and differential diagnoses of atypical choroid plexus papilloma.Methods Radiographical pattern,histological observation and immunohistochemical studies were conducted in two cases with atypical choroid plexus papilloma,and histopathologic features and differential diagnosis were discussed with review of the literature.Results Histopathological feature was morphological variety with well-differentiated part and poor-differentiated areas,the latter showed malignant morphological features of choroid plexus tumor,including increased cellular density,sheet-like growth of tumor cells and brisk mitotic activity（3-5/10 HPF）.Immunohistochemically,tumor cells expressed cytokeratin（CK）,S-100 and Vimentin,and weakly positive for Syn.Imunohistochemical staining were negative for EMA,GFAP and CEA.The Ki-67 labeling-positive tumor cells were more than 5% locally.Conclusion Clinical data,such as age of the patient and the accurate location of the tumor are essential for the final diagnosis.Strictly controlling the diagnosis criterion of atypical choroid plexus papilloma and reasonable application of immunohistochemistry are extremely important for the pathological diagnosis and differential diagnoses.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2012年第9期831-832,共2页
Journal of Apoplexy and Nervous Diseases
关键词
不典型脉络丛乳头状瘤
病理
桥小脑角区
免疫组织化学
Atypical choroid plexus papilloma
Pathology
Cerebellopontine angle
Immunohistochemistry
