摘要
目的探讨T_(1)WI增强全域灰度直方图在脉络丛乳头状瘤与室管膜瘤鉴别诊断中的价值。方法回顾性分析术前行常规MRI增强扫描并在术后经病理证实的54例脑室肿瘤患者资料,其中脉络丛乳头状瘤25例、室管膜瘤29例。采用MaZda软件分别在两组肿瘤的T_(1)WI增强矢状位图像上勾画所有层面的肿瘤实质区域,行灰度直方图分析,观察二者的直方图特征,将获得的均值(Mean)、变异度(Variance)、峰度(Kurtosis)、偏度(Skewness)、第1百分位数(Perc.1%)、第10百分位数(Perc.10%)、第50百分位数(Perc.50%)、第90百分位数(Perc.90%)、第99百分位数(Perc.99%)9个特征参数进行统计分析,比较脉络丛乳头状瘤与室管膜瘤特征参数间的差异。绘制受试者工作特征曲线(ROC)并计算曲线下面积(AUC),评价直方图特征参数在脉络丛乳头状瘤和室管膜瘤中的鉴别诊断效能。结果脉络丛乳头状瘤与室管膜瘤的Mean、Skewness、Perc.1%、Perc.10%、Perc.50%、Perc.90%和Perc.99%7个直方图参数有统计学差异(P值均<0.05),AUC分别为0.848、0.761、0.680、0.803、0.841、0.823、0.790;直方图参数Variance、Kurtosis无统计学差异(P>0.05)。其中Mean、Perc.50%的诊断效能较高,最佳临界值分别为90.942、92.375,诊断的敏感度及特异度分别为100%和62.07%,96%和65.52%。结论T_(1)WI增强全域直方图分析在脑室内脉络丛乳头状瘤和室管膜瘤的鉴别诊断中具有很大价值,其中Mean与Perc.50%参数的诊断效能较高。
Objective To study the value of whole-tumor gray histogram derived from enhanced T1-weighted images in differential diagnosis of choroid plexus papilloma and ependymoma.Methods Data of 54 patients with ventricular tumors confirmed by operation and pathology after conventional enhanced MRI scan were retrospectively collected,including 25 patients with choroid plexus papilloma and 29 patients with ependymoma.MaZda software was used to delineate the levels of tumor parenchyma areas on the enhanced T1-weighted sagittal images of the two groups and gray histogram analysis was performed to observe the histogram characteristics of the two groups.Statistical analysis was conducted on 9 characteristic parameters obtained,namelyMean,Variance,Kurtosis,Skewness,Perc.1%,Perc.10%,Perc.50%,Perc.90%,Perc.99%,to compare the differences of characteristic parameters between choroid plexus papilloma and ependymoma.The receiver operating characteristic curve was drawn and the area under curve was calculated to evaluate the efficacy of histogram characteristic parameters in the differential diagnosis of the two tumors.Results There were statistical differences between choroid plexus papilloma and ependymoma in Mean,Skewness,Perc.1%,Perc.10%,Perc.50%,Perc.90%,and Perc.99%(all P<0.05),with the areas under receiver operating characteristic curve of 0.848、0.761、0.680、0.803、0.841、0.823、0.790,respectively.There were no statistical differences in histogram parameters Variance and Kurtosis(both P>0.05).Mean and Perc.50%had the higher diagnostic efficiency,with the optimal threshold for 90.942、92.375,the sensitivity and specificity of diagnosis were 100%、62.07%and 96%、65.52%.Conclusion Whole-tumor histogram analysis of enhanced T1-weighted images has great value in differential diagnosis of choroid plexus papilloma and ependymoma in the ventricle,and the Mean and Perc.50%have superior diagnostic performance.
作者
张蕊
陈翰林
白岩
魏巍
林睿娟
王梅云
ZHANG Rui;CHEN Hanlin;BAI Yan(Department of Medical Imaging,The People's Hospital of Zhengzhou University(Henan Provincial People's Hospital),Zhengzhou,Henan Province 450003,P.R.China)
出处
《临床放射学杂志》
北大核心
2021年第2期201-206,共6页
Journal of Clinical Radiology
基金
国家重点研发计划项目(编号:2017YFE0103600)
国家自然科学基金项目(编号:81601466、81720108021)
中原千人计划项目(编号:ZYQR201810117)
河南省科技攻关计划项目(编号:182102310496)
河南省医学科技攻关计划项目(编号:2018020403)
