摘要
目的:探讨血管内皮生长因子(VEGF)936C/T基因多态性及其等位基因与重度子痫前期遗传易感性的相关关系。方法:采用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)分别检测84例重度子痫前期患者和71例正常对照组的VEGF 936C/T基因多态性突变位点的基因型。结果:重度子痫前期患者中VEGF 936CT、TT基因型高于正常对照组,VEGF 936CC基因型低于正常对照组,差异有统计学意义(P<0.05);重度子痫前期组VEGF 936C等位基因低于正常对照组,VEGF 936T等位基因高于正常对照组,差异有统计学意义(P<0.05)。调整混杂因素后,正常对照组、重度子痫前期组人群中携带CT、TT基因型组发生重度子痫前期的危险性是CC基因型组的2.732倍。结论:携带VEGF 936CT、TT基因型者患重度子痫前期的危险性增加,VEGF 936C/T基因多态性与重度子痫前期的发生具有相关性。
Objective：To explore the relationship between VEGF 936C/T gene polymorphism and susceptibility of severe preeclampsia.Methods：Gene polymorphism of VEGF936C/T of 84 patients with preeclampsia（study group） and 71 normal pregnant women（control group） was detected with PCR-RFLP method.Results：VEGF 936 CT,TT genotype of the study group was higher than that of the control group,VEGF 936CC genotype of the study group was lower than that of the control group,and the difference was statistically significance（P0.05）;VEGF 936 C allele of the study group was lower than that of the control group,VEGF 936 T allele of the study group was higher than that of the control group,and the difference was statistically significant（P0.05）;In the same case,the incidence of severe preeclampsia in the CT and TT genotype was 2.732 times of CC genotype.Conclusion：The cases with CT,TT genotypes have high risk of preeclampsia,VEGF 936 C/T gene polymorphism are relevant with severe preeclampsia
出处
《中国妇幼保健》
CAS
北大核心
2011年第32期5052-5055,共4页
Maternal and Child Health Care of China
基金
唐山市科技支撑项目〔09130221a〕
