摘要
目的探讨喹硫平与丙戊酸钠治疗双相情感障碍抑郁发作的临床疗效和安全性，以及对患者生活质量的影响。方法将68例双相情感障碍抑郁发作患者随机分为两组，每组34例，研究组口服喹硫平治疗，对照组口服丙戊酸钠治疗，观察8周。于治疗前及治疗第1周、2周、4周、6周、8周末采用汉密顿抑郁量表评定临床疗效，治疗8周末采用生活质量问卷评定生活质量，副反应量表评定不良反应。结果治疗各时段两组汉密顿抑郁量表评分均较治疗前显著下降，研究组治疗第1周、2周、4周、6周末较对照组下降更显著（P〈0．05或0．01）；治疗8周末，研究组显效率为87．5％，对照组为66．7％，研究组显著高于对照组（X^2=3．97，P％0．05）；治疗8周末研究组生活质量问卷除物质生活维度分无显著变化外（P〉0．05），总分及其他维度分均显著高于治疗前（P〈0．01），且显著高于对照组（P〈0．01）。两组不良反应发生率较低，且程度较轻微，研究组发生率为36．82％，对照组为33．66％，两组差异无显著性（P〉0．05）。结论喹硫平治疗双相情感障碍抑郁发作效果显著，起效快，安全性高，依从性好，能显著提高患者的生活质量，显著优于丙戊酸钠治疗。
Objective To explore the efficacy, safety and influence on quality of life of queitiapine vs. sodium valproate in the treatment of depressive episode of bipolar affective disorder. Methods Sixty-eight patients were randomly assigned to two groups of 34 ones each, reseach group took orally queitiapine and control group did sodium valproate for 8 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） before treatment and at the end of the 1^ST, 2^nd, 4^th, 6^th and 8^th week, quality of life with the Generic Quality of Life Inventiry-74 （GQOLI-74） at the end of the 8^th week and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results The HAMD scores of both groups in each period lowered more significantly compared with pretreatment, so did those in the research than in the control group at the end of the 1^st, 2^nd, 4^th and 6^th week （P〈0.05 or 0.01） ; at the end of the 8th week, obvious effective rate was significantly higher in the research than in the control group （87.5% vs. 66.7%, X^2==3.97, P〈0.05）; at the end of the 8th week, except material life （P〉0.05）, the total and other di- mensions＇scores of the GQOLI-74 were significantly higher compared with pretreatment in the research （P〈0.01） and with control group （P〈0.01）. Adverse reactions of both groups had low incidences which had no significant differences （36.82% vs. 33.66%, P〉0.05） and were mild. Conclusion Quetiapine has an advantage over sodium valproate in efficay, taking effect, safety, compliance and improving quality of life in the treatment of depressive episode of bipolar affective disorder.
出处
《临床心身疾病杂志》
CAS
2011年第5期395-397,共3页
Journal of Clinical Psychosomatic Diseases
