摘要
目的探讨喹硫平联合丙戊酸钠治疗双相情感障碍躁狂发作的疗效及对认知功能的影响。方法选取2013-2014年我院收治的双相情感障碍躁狂发作患者80例,随机平均分为观察组与对照组,分别行丙戊酸钠联合喹硫平与利培酮治疗,均早晚2次服用,持续6周。于治疗前和治疗6周后采用杨氏躁狂量表(YRMS)评定临床疗效,采用威斯康星卡片分类测验(WCST)、持续操作测验(CPT)和霍普金斯词语学习测验修订版(HVLT-R)评定认知功能。结果观察组临床治愈率、显效率、总有效率与对照组相比均无显著性差异(P>0.05)。治疗后2组完成分类数、错误应答数、持续应答数均明显改善,持续注意水平明显改善,观察组错误应答数与持续应答数改善更为明显(P<0.05)。结论喹硫平联合丙戊酸钠能够有效治疗双相情感障碍躁狂发作,改善患者的部分认知功能。
Objective To investigate the curative efficacy of sodium valproate combined with quetiapine in the treatment of manic episode of bipolar disorder and influence on cognitive function.Methods A total of 80 patients with manic episode of bipolar disorder admitted to our hospital from 2013 to 2014,and were randomly assigned to observation group and control group treated with sodium valproate combined with quetiapine quetiapine and risperidone,respectively.All drugs were taken in the morning and night,the duration of treatment was 6weeks.Young manian rating scale（YMRS）at the baseline and treated 6weekends was used to evaluate clinical curative efficacy.The cognitive function was assessed by Wisconsin Card Sorting Test（WSCT）,Cotiuous Performance Task（CPT）and Hopkins Verbal Learning Test Tevised（HVLT-R）.Results The clinical cure rate,explicit effective rate and total effective rate of the two groups after 6weeks were no significantly different（P〈0.05）.After treatment,complete classification number,error responses,sustained responses of two groups were significantly improved and sustained attention level improved significantly,the error responses and sustained responses of observation group improved more obviously（P〈0.05）.Conclusion Quetiapine combined with sodium valproate can effectively treat manic episode of bipolar disorder,and improve the cognitive function.
出处
《中国实用神经疾病杂志》
2016年第11期66-68,共3页
Chinese Journal of Practical Nervous Diseases
