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人类白细胞抗原-G免疫调节与自身免疫病研究进展 被引量：2

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摘要 人类白细胞抗原G（Human leukocyte antigenG，HLA-G）是一种非经典的主要组织相容性复合体（MHC）-I类分子，能够通过与抑制性受体结合作用，调节树突状细胞的分化成熟，T细胞、B细胞、自然杀伤细胞的功能以及调节性T细胞的增殖。自HLA—G首次发现于母胎界面的绒毛外滋养细胞，已从母胎免疫耐受逐渐扩展到肿瘤、器官移植以及自身免疫病等许多领域。本文就HLA-G的结构、功能及其在自身免疫病方面的相关研究进展做一综述。
作者 陈海凤 孙凌云
机构地区 南京医科大学鼓楼临床医学院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第7期493-496,共4页 Chinese Journal of Rheumatology
基金 基金项目：江苏省科教兴卫工程项目（RC2007004）
关键词 人类白细胞抗原 免疫调节 自身免疫病 临床研究
分类号 R392 [医药卫生—免疫学]
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参考文献26

  • 1Carosella ED, Moreau P, Maoult JL, et al. HLA-G molecules: from maternal-fetal tolerance to tissue acceptance. Adv Immunol, 2003, 81: 199-252.
  • 2Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for the factors of HLA system. Tissue Antigens, 2002, 60: 407- 446.
  • 3Discorde ML, Moreau P, Sabatier P, et al. Expression of HLA-G in human cornea, an immune-prlvileged tissue. Hum Immunol, 2003, 64: 39-,~4.
  • 4Ito T, Ito N, Saathoff M, et al. Immunology of the human nail apparatus: the nail matrix is a site of relative immune privilege. J Invest Dermatol, 2005, 125:1139-1148.
  • 5Pistoia V, Morandi F, Wang XH, et al. Soluble HLA-G: are they clinically relevant. Semin Cancer Biol, 2007, 17: 469-479.
  • 6Carosella ED, Moreau P, LeMaoult J, et al. HLA-G: from biolo- gy to clinical benefitS. Trends Immunol, 2008, 29: 125-32.
  • 7Gotherstrom C, West A, Liden J, et al. Difference in gene ex- pression between human fetal liver and adult bone marrow mes- enchymal stem cells. Haematologica, 2005, 90: 1017-1026.
  • 8Park B, Lee S, Kim E, et al. The truncated cytoplasmic tail of HLA-G serves a quality-control function in post-ER compater- ments. Immunity, 2001, 15: 213-234.
  • 9Liang Sy, Ristich V, Arase H, et al. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6-STAT3 signaling pathway. Proc Natl Acad Sci USA, 2008, 105(24): 8357-8362.
  • 10LeMaoult J, Zafaranloo K, Le Danff C, et al. HLA-G up-regu- lates ILT2,ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK eells, and T cells. FASEB J, 2005, 19: 662-664.

同被引文献30

  • 1Yan WH.HLA-G expression in cancer:potential role in diagno sis,prognosis and therapy[J].Endocr Metab Immune Disord Drug Targets,2011,11:76-89.
  • 2Arnett FC,Edworthy SM,Bloch DA,et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31:315-324.
  • 3Prevoo ML,Van't Hof MA,Kuper HH,et al.Modified disease activity scores that includes twenty-eight joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis[J].Arthritis Rheum,1995,38:44-48.
  • 4Pistoia V,Morandi F,Wang X,et al.Soluble HLA-G:are they clinically relevant?[J].Semin Cancer Biol,2007,17:469-479.
  • 5Verbruggen LA,Rebmann V,Demanet C,et al.Soluble HLA-G in rheumatoid arthritis[J].Hum Immunol,2006,67:561-567.
  • 6Rizzo R,Farina I,Bortolotti D,et al.HLA-G may predict the disease course in patients with early rheumatoid arthritis[J].Hum Immunol,2013,74:425-432.
  • 7Mitsdoerffer M,Schreiner B,Kieseier BC,et al.Monocyte derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo:rationale for the therapy of multiple sclerosis[J].J Neuroimmunol,2005,159:155-164.
  • 8Monsiváis-Urenda AE,Baranda L,Alvarez-Quiroga C,et al.Expression and functional role of HLA-G in immune cells from patients with systemic lupus erythematosus[J].J Clin Immunol,2011,31:369-378.
  • 9Rebmann V,Busemann A,Lindemann M,et al.Detection of HLA-G5 secreting cells[J].Hum Immunol,2003,64:1017-1024.
  • 10LeMaoult J,Caumartin J,Daouya M,et al.Immune regulation by pretenders:cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells[J].Blood,2007,109:2040-2048.

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中华风湿病学杂志
2011年 第7期

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