摘要
细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于半胱天冬酶-1（caspase-1），并伴有大量促炎症因子的释放。细胞焦亡的形态学特征、发生及调控机制等均不同于凋亡、坏死等其他细胞死亡方式。研究表明，细胞焦亡广泛参与感染性疾病、神经系统相关疾病和动脉粥样硬化性疾病等的发生发展，并发挥重要作用。对细胞焦亡的深入研究有助于认识其在相关疾病发生发展和转归中的作用，为临床防治提供新思路。
Pyroptosis is a new form of programmed cell death, which is dependent on caspase-1 activation and leads to the release of pro-inflammatory cytokines. The molecular mechanisms, morphological and biochemical properties of this form of cell death are distinct from necrosis or apoptosis. Studies have shown that pyroptosis plays a significant role in a variety of disease, such as infection, nervous system disease and atheroselerosis. Better understanding of pyroptosis will not only give insight into disease pathogenesis, but can also lead to the development of new therapeutic strategies for treatment of these cell death-related diseases.
出处
《国际免疫学杂志》
CAS
北大核心
2011年第3期213-216,共4页
International Journal of Immunology
