1Okamura H, Tsutsui H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-γproducing by T cells [J].Nature,1995,378:88~91.
2Ushio S, Namba M,Okura T,et al. Cloning of the cDNA for human IFN-gamma-inducing factor,expression in Escherichia ciol and studies on the biologic activities of the protein [J].J Immunol, 1996,156:4 274~4 279.
3Kikuchi T, Akasaki Y, Joki T, et al. Antitumor activity of ihterleukin-18 on mous glioma cells[J].J Immunotherapy,2000,23(2):184~189.
4Yoshimoto T, Nagai N ,Ohkusu K ,et al. LPS-stimulated SJL macrophages proguce IL-2 and IL-18 that inhibit IgE production from CD3intIL-2R beta +T cells[J].J Immunol, 1998,161(3):1483~1 492.
5Rothe H, Jenkins N A, Copeland N G, et al. Active of autoimmune diadetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2 [J].J Clin Invest,1997,99:469~453.
6Gracie J A, Forsey R J, Chan W L, et al. A proinflammatory role for IL-18 in rheumatoid arthritis [J].J Clin Invest,1999,104(10):1 393~1 041.
7Sylvie Fournout ,Charles M. Dozios,Martine Yerle et al.Cloning, chromosomal location,and tisse expression of the gene for pig interleukin [J].J Immunogenetics,2000,51:358~365.
8Ghayur T, Banerjee S, Hugunin M, et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFNgamma production .Nature, 1997,386 (6625):619~623.
10Coughlin C M, Salhany K E, Wysocka M et al. Interleukin12 and interleukin-18 synergistically induce murine tutor regression which involve inhibition of angiogenesis[J].J Clin Invest,1998,101:1441~1452.
二级参考文献15
1Okamura H,Tsutsi H,Komatsu T et al.Cloning of a new cytokine that induce IFN-gamma production by T cell[J]. Nature, 1995;378(6552) :88-91.
2Ushio S, Namba M, Okura T et al. Cloning of the cDNA for human IFN-inducing factor, expression in Escherichia coli,and studies on the biologic activities of the protein[ J]. J Immunol, 1996; 156(10) :4274-4279.
3Lochner M, Wagner H, Classen M et al. Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo[J].J Immunol Methods,2002;259(1-2) : 149-157.
4Seya T,Matsumoto M,Shiratori I et al.Protein polymorphism of human IL-18 identified by monoclonal antibodies[J]. Int J Mol Med, 2001;8(5) :585-590.
5Okamoto M, Kato S, Oizumi K et al. Interleukin 18(IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia[ J]. Blood,2002;99(4) : 1289-1298.
6Pages F, Berger A, Lebel-Binay S et al. Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract[J]. Immunol Lett,2000;75( 1 ) :9-14.
7Hara S,Nagal H,Miyake H et al. Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunity[J]. J Urol,2001 : 165(6Ptl ) :2039-2043.
8Dupre L,Dremer L,Wolowczuk I et al.Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine schistosoma mansoni infection[J]. Vaccine,2001 ; 19(11-12) : 1373-1380.
9Wang Q,Yu H,Ju D W et al.Intratumoral IL-18 gene transfer improves therapeutic efficacy of antibody-targeted superantigen in established murine melanoma[J].Gene Ther,2001 ;8(7) :542-550.
10Shida K,Shiratori I,Matsumoto M et al.An altemative form of IL-18 in human blood plasma:complex formation with IgM defined by monoclonal antibodies[J].J Immunol, 2001; 166( 1 ) : 6671-6679.