摘要
目的:评价不同生物材料修复骨缺损的性能与效果,寻找适合生物材料以利于临床应用。方法:以"生物材料,骨缺损,骨髓基质干细胞,细胞因子,组织工程"为中文关键词,以"biological materials,bone defect,bone marrowstroma lcells,Cytokine,tissue engineering"为英文关键词,采用计算机检索1995-01/2010-01相关文章。纳入与有关生物材料与组织工程骨缺损修复相关的文章;排除重复研究或Meta分析类文章。以22篇文献为主重点讨论了骨缺损修复生物材料及其性能。结果:目前骨组织工程支架材料主要有两类:一类是天然生物衍生材料,由天然生物组织经一系列理化方法处理而得,如胶原、珊瑚、生物衍生骨等。另一类是人工合成材料,主要为生物陶瓷和高分子材料,如钙磷陶瓷、自固化磷酸钙、聚乳酸、聚乙内酯,聚乙烯乙二醇等。目前,单一的材料,无论是生物陶瓷还是高分子(天然或人工合成),都不能满足骨组织修复的要求,因而复合支架材料的研究备受瞩目。如纳米羟基磷灰石与胶原、羟基磷灰石与磷酸三钙、羟基磷灰石与聚乳酸-聚羟乙酸复合等。结论:复合支架材料能保证足够的强度而且能有效结合种子细胞和生长因子,有利于组织工程骨的构建。
OBJECTIVE：To evaluate the properties and effect of different biomaterials for the repair of bone defects,and to search a suitable biomaterial for clinical applications.METHODS：A computer-based online search was performed for articles between January 1995 and January 2010 using the key words of ＂biological material,bone,bone marrow stromal cells,cytokines,tissue engineering＂ in Chinese and in English.Articles regarding the biomaterials and tissue engineering bone defects repair were included;duplicated research or Meta analysis were excluded.A total of 22 papers mainly focused on the biomaterials and their properties for restoration of bone defects.RESULTS：At present,bone tissue engineering scaffolds are divided into two types：one is natural bio-derived materials obtained by a series of physical and chemical processes from natural tissues,such as collagen,coral,bio-derived bone and so on.The other is artificially synthetic materials,mainly includingr bio-ceramic and polymer materials,such as calcium phosphate ceramic,self-cured calcium phosphate,polylactic acid,polyethylene lactone,polyethylene glycol and so on.Currently,a single material,either bio-ceramic or polymer （natural or synthetic）,can not meet the requirements of bone tissue repair,and thus composite scaffold attracts much attention,such as nano-hydroxyapatite and collagen,hydroxyapatite and tricalcium phosphate,hydroxyapatite and polylactic acid-glycolic acid compound.CONCLUSION：The composite scaffolds can ensure sufficient strength and can effectively combine the seed cells with growth factors,thus being conducive to construct tissue engineered bone.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第51期9679-9682,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
