摘要
目的 :评估纳米羟基磷灰石 /胶原骨 (nano hydroxyapatite/collagen ,NHAC ,简称人工骨 )材料在骨折后骨缺损应用中的临床效果。方法 :对 2 1例骨折后骨缺损患者应用NHAC骨修复材料进行手术植入治疗 ,连续 6～ 13个月临床观察随访。结果 :2 1例中 2例失访。获随访的 19例患者无局部或全身不良反应。 19例中 2例因外伤或过早负重 ,致内固定钢板折断再骨折 ,予重新手术内固定 ,其余 17例均达临床愈合。X线片显示 ,术后 1～ 3个月材料植入区与缺损周围的骨组织间界限模糊有新骨形成 ,3～ 6个月材料植入区内有明显的新骨长入 ,骨修复材料与骨组织融合一体 ,达到骨性连接 ,骨缺损己基本修复。 6～ 12个月植骨塑形改建。结论 :NHAC骨修复材料具有良好的生物相容性和骨传导性 ;其良好的材料 -细胞界面使材料本身便具备与骨键合的能力 ;其三维多孔结构便于骨组织的长入 ;其生物降解性有利于骨组织的改建和塑形 ,具有良好的临床应用前景。
Objective:To evaluate the clinical results of nano-hydroxyapatite/collagen(NHAC) as a bone graft substitute in repair of bone defects. Methods:Twenty one patients were treated with a bone graft substitute,NHAC for bone defects caused by fracture. Implantation amount was decided by extent of bone defects,averaging from 0.4 to 2 grams. Clinical and roentgenographic assessments were performed consecutively at follow-up periods of 6 to 13 months. Results:The results of 19 cases were obtained. No adverse reactions to the graft materials were found in all patients. Among the 19 cases,two cases were re-fracture and with broken fixator,the reason was the early removal of the external fixator,and they didn’t heal. The other 17 cases got clinical healing,and the healing time averaged from 3 to 6 months after operation. The interface between normal bone and grafted defect became vague in advance of new bone formation by 1 to 3 months roentgenographically,and obliteration of the interface was evident at 3 to 6 months. Conclusion:NHAC had good biocompatibility and biodegradability. It was a safe,effective bone graft substitute material for the filling of defects caused by trauma.
出处
《江苏大学学报（医学版）》
CAS
2004年第4期292-294,共3页
Journal of Jiangsu University：Medicine Edition
关键词
纳米羟基磷灰石
胶原
骨折
缺损
Nano-hydroxyapatite
Collagen fracture
Defect
