摘要
目的:探讨MMP-9、VEGF在喉鳞癌组织中的表达及临床病理学意义。方法:①免疫组化法检测75例喉癌患者MMP-9及VEGF的表达情况;②利用Spearman秩相关检验分析MMP-9及VEGF的表达与喉癌相关临床参数的关系。结果:①MMP-9表达在声门上型喉癌中与颈淋巴结转移存在正相关(r=0.553,P=0.011),而在声门型喉癌中却无相关性(r=0.219,P=0.382);VEGF表达在声门上型喉癌中与颈淋巴结转移存在正相关(r=0.362,P=0.018),而在声门型喉癌中却无相关性(r=0.189,P=0.453);②MMP-9表达与VEGF表达之间存在正相关(r=0.775,P=0.000),且MMP-9表达、VEGF表达均与临床分期、颈淋巴结转移呈正相关(r=0.468,P=0.003;r=0.402,P=0.012),与年龄等因素无关。结论:MMP-9、VEGF的表达与喉鳞癌的侵袭、颈淋巴结转移有关,两者可能在喉鳞癌的发生、发展中起重要作用。
Objective： To investigate the expression and clinical significance of MMP-9 and VEGF in human laryngeal squamous cell carcinoma. Methods： MMP-9 and VEGF expression in surgically resected tissue samples of laryngeal carcinomas （n=75） were examined immunohistochemically, and their correlations with clinicopathological factors were analyzed. Results： ①Significant positive correlation was revealed between MMP-9 expression and lymph node metastasis in supraglottic carcinoma （r=0.553, P=0.011）, and no correlation in glottic carcinoma （r=0.219, P=0.382）; and significant positive correlation was revealed between VEGF expression and lymph node metastasis in supraglottic carcinoma （r=0.362, P=0.018）, and no correlation in glottic carcinoma （r=0.189, P=0.453）. ②The expression of MMP-9 was positively correlated with VEGF （r= 0.775, P=0.000）, the expressions of MMP-9 and VEGF were positively correlated with clinical staging of laryngeal carci noma and the neck lymph node metastasis （r=0.468, P=0.003; r=0.402, P=0.012）. In contrast, the level of MMP-9 and VEGF expression was not correlated with age and so on. Conclusion： MMP-9 and VEGF may play an important role in the tumor invasion and lymph nodal metastasis of laryngeal squamous cell carcinoma.
出处
《中国医药导报》
CAS
2010年第29期12-14,共3页
China Medical Herald
关键词
喉鳞癌
MMP-9
VEGF
免疫组化
Laryngeal squamous cell carcinoma
MMP-9
VEGF
Immunohistochemistry
