摘要
线粒体ATP合酶是能量合成过程中的一个关键酶。该酶由水溶性的F1和跨膜的脂溶性F02个亚基组成,其中F1亚基由核基因编码,F0亚基由线粒体ATP6和ATP8基因以及核基因共同编码。该酶利用线粒体内膜两侧质子梯差形成的势能,通过结合改变机理旋转合成ATP,达到了很高的能量转化效率。因此,研究其基因组成及作用机制对分析和改良与动物能量代谢密切相关的重要经济性状及其基因效应具有重要价值。本文对线粒体ATP合成酶的基因组成及其作用机制进行了阐述。
Mitochondrial ATPase （mtATPase） complex plays vital roles in the energy currency of the cell. The enzyme is composed of a water - soluble F1 moiety in the cytoplasm and a fat - soluble Fo moiety in the membrane. F1 moiety is coded by nuclear, F0 moiety is coded by some nuclear genes and two mitochondrial genes, ATP6 and ATP8. According to the binding change mechanism, the enzyme transform potential energy of proton grads to ATP with high efficiency by rotating. Thus, it is important to study the gene components and biochemical mechanism of mtATPase for improving some important economic traits of domestic animals, especially traits related to energy metabolism or growth rate. This review summarizes gene components of mitochondrial ATP synthase and the mechanism of its action.
出处
《中国畜牧杂志》
CAS
北大核心
2010年第7期64-68,共5页
Chinese Journal of Animal Science
基金
国家高新技术研究发展计划(863)(2008AA10Z136)
转基因重大专项(2008ZX08012-001)
