摘要
副肿瘤性天疱疮(PNP)是一种自身免疫性大疱性皮肤病,常伴发肿瘤。临床表现为严重的黏膜糜烂和多形性皮肤损害。PNP的主要病理学特点为表皮基底细胞层上棘细胞松解性水疱及个别坏死的角质形成细胞。患者血清中可存在致病性的自身抗体,其产生与伴发的肿瘤有关。早期诊断及手术及时切除肿瘤是成功治疗的关键。
Paraneoplastic pemphigus （PNP） is an autoimmune blistering skin disease associated with neoplasmas. Clinically, it is characterized by severe mucosal erosions and various cutaneous lesions. Suprabasal acantholysis and cleft with scattered necrotic keratinocytes are the unique histopathological features of PNP. The pathogenic autoantibodies existed in PNP sera, and their production was correlated with the associated tumor. Early detection and resection of the tumor are essential for the treatment of the disease.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2009年第5期654-658,共5页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(30671890)~~
关键词
副肿瘤性天疱疮
基础研究
临床研究
paraneoplastic pemphigus
basic research
clinical research
