期刊文献+

二甲双胍治疗多囊卵巢综合征肥胖型临床分析 被引量:4

在线阅读 下载PDF
导出
摘要 目的:观察二甲双胍治疗多囊卵巢综合征(PCOS)肥胖型疗效。方法:将40例PCOS肥胖患者随机分为两组,分别用二甲双胍和克罗米芬(CC)治疗,并观察两组疗效以及治疗前后体重指数(BMI)、胰岛素水平和葡萄糖耐量试验(OGTT)的变化。结果:治疗组排卵率(80%)明显高于对照组(20%)在BMI、胰岛素水平和OGTT改善方面两组比较,差异有显著性。结论:二甲双胍能明显改善PCOS的临床症状,提高排卵率,改善肥胖,特别是对耐克米罗芬PCOS有良好的治疗作用。
作者 朱艳红
出处 《医学理论与实践》 2008年第10期1195-1196,共2页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献4

  • 1Me Gahon A,Bissonnette R, Schmitt M, et al. Bcr-ABL maintains resistance of chromic myelogeneous leukemia cells to apoptotie cell death[J]. Blood, 1994,83:1179-1187.
  • 2姜荣华,徐望明.多囊卵巢综合征的胰岛素抵抗研究进展[J].国外医学(妇幼保健分册),2004,15(2):113-116. 被引量:15
  • 3Nestler JE, Jakubowicz DJ. Decreases in ovarian cytochome P450c17alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome[J]. N Engl J, 1996,335 (9) : 617-623.
  • 4Nestler JE, Jakubowicz DJ. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17apha activity and serum androgens[J]. J Clin Endocrinol Metab, 1997,82(12) : 4075-4079.

二级参考文献27

  • 1Fruzzetti F, Bersi C, Parrini D, et al. Effect of long-term naltrexone treatment on endocrine, profile, clinical fearures,and insulin sensitivity in obese women with polycystic ovary syndrome[J]. Fertil Steril,2002,77(5) :936-944.
  • 2Tucci S, Futterweit W, Concepcion E S, et al. Evidence for associateion of polycystic ovary syndrome in Caucasian women with a marker at the insulin receptor gene locus [J]. J Clin Endocrinol Metab, 2001,86: 446-449.
  • 3Villuendas G, Escobar M H F, Tosi F, et al. Association between the D19S884 marker at the insulin receptor geng locus and polycystic ovary syndrome [J]. Fertil Steril, 2003,79 (l):219-220.
  • 4Siegel S, Futterweit W, Davies T F, etal. A A/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome[J]. Fertil Steril,2002,78(6) :1240-1243.
  • 5Romualdi D, Guido M, Clampelli M, et al. Selective effects of Pioglitazone on insulin and androgen abnormallyties in normoand hyperinsulineaemic obese patients with polycystic ovary syndrome[J]. Hum Peprod,2003,18(6): 1210-1218.
  • 6Baranowska B, Radzikowska M, Wasilewska D E, et al.Neuropeptide Y, leptin, galanin and insulin in women with polycystic ovary syndrome [J]. Gynecol Endocrinol, 1999, 13(5) :344-351.
  • 7Ia M A, Morgante G, Palumbo M, et al. Insulin-lowering treatment reduces aromatase activeity in response to folliclestimulating hormone in women with polycystic ovary syndrome[J]. Fertil Steril,2002,78(6): 1234-1239.
  • 8Huber B M M, Carey D G P, Norman R J, et al. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: Role of insulin sensitivity and luteinizing hormone[J]. J Clin Endocrinol Metab,1999,84(4):1470-1474.
  • 9Azziz R, Ehrmann D A, Legro R S, et al. Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome[J]. Fertil Steril,2003,79(4):932-937.
  • 10Shobokshi A, Shaarawy M. Correction of insulin resistance and hyperandrogenism in polycystic ovary syndrome by combined rogelitazone and clomiphene citrate therapy[J] .J Soc Gynecol Investig,2003,10(2) :99-104.

共引文献14

同被引文献28

引证文献4

二级引证文献107

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部