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不同剂量来曲唑对耐克罗米酚的PCOS患者促排卵治疗的临床观察 被引量：3

Clinical study on various doses of letrozole for ovulation induction in clomiphene-resistant patients with ploycystic ovary syndrome
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摘要 目的:观察不同剂量来曲唑(LE)对耐克罗米酚的多囊卵巢综合征(PCOS)患者促排卵治疗的临床疗效。方法:回顾性分析73例耐克罗米酚的PCOS患者的临床资料。结果:本组均未出现卵巢过度刺激综合征(OHSS)及多胎妊娠。结论:芳香化酶抑制剂-来曲唑可以用于对耐克罗米酚的PCOS患者促排卵治疗,促排卵的效果与剂量有关,妊娠率与剂量无关,临床应用过程中未见明显不良反应。 Objective ：To observe the clinical effect of various doses of letrozole for ovulation induction in clomiphene （CC）-resistant patients with ploycystic ovary syndrome （PCOS）.Methods ：The clinical data in 73 clomiphene-resistant patients with PCOS were analysed retrospectively.Results ：The ovary overstimulation syndrome and multiple pregnancy were not found in this group.Conclusion：The various doses of letrozole can be used as a medicine for ovulation induction in clomiphene-resistant patients with PCOS.The effect of ovulation induction is associated with dose of letrozole, but the pregnancy rate is not associated with dose of letrozole, without obvious adverse reaction.
作者 许敏 刘云
机构地区 乐山市五通桥区计划生育指导站 重庆医科大学附属第二医院妇产科
出处 《现代医药卫生》 2008年第21期3197-3198,共2页 Journal of Modern Medicine & Health
关键词 多囊卵巢综合征 来曲唑 克罗米酚 促排卵 卵泡发育 PCOS Letrozole Clomiphene critate Ovulation induction Follicular development
分类号 R71 [医药卫生—妇产科学]
  • 相关文献

参考文献9

  • 1Mitwally MF, Casper RF.Use of an aromatase inhibitor for induction of ovulation in patiems with all inadequate response to clomiphene citrate[J].Fertil Steril, 2001,75 ( 2 ) :305.
  • 2朱桂金,徐蓓.PCOS患者诱发排卵的方案[J].实用妇产科杂志,2007,23(3):131-134. 被引量：36
  • 3The Rotterdam ESHR/ASRM-sponsored PCOS consensus workshop group.Revised 2003 consensus on diagnostic criteria and long term health risks related to polycysfic ovary syndrome(PCOS)[J].Hum Repord, 2004,19(1):41.
  • 4Parsanezhad ME ,Alborzi S,Zarei A ,et al.Insulin resistance in clomiphene responders and non-responders with polycystie ovarian disease and therapeutic effects mefformin[J].Int Gynecol Obstet,2001,75(1):43.
  • 5Quintero RB, Urban R,Lathi RB ,et al. A comparison of letrozole to gonadotropins for ovulation induction in subjects who failed to conceive with clomiphene citrate[J].Fertll Ateril,2007,88(4):879.
  • 6Al-Fadhli R,Sylvestre C,Buckett W,et al.A randomized trail of superovulation with two diferent doses of letrozole[J].Fertll Steri ,2006, 85(1) : 161.
  • 7Badawy A, Metwally M,Fawzy M.Randomized controlled trial of three doses of letrozole for ovulation induction in patients with unexplained infertility[J].Reprod Biomed Online, 2007,1(5):559.
  • 8Al-fozan H ,Al-Khadouri M ,Tan SL,et al.A randomized trial of letrozole versus elomiphene citrate in women undergoing super ovulation[J].Fertil Steril,2004,82(6) :561.
  • 9Mitwally MF,Casper RF.Aromatase inhibitors for ovulation induction[J]. J Clin Endocrinol Metab,2006,91(3):760.

二级参考文献4

  • 1Nardo LG.Management of anovulatory infertility associated with polycystic ovary syndrome:tamoxifen citrate an effective alternative compound to clomiphene citrate[J].Gynecol Endocrinol,2004,19(5):235-238.
  • 2Beck JI,Boothroyd C,Proctor M,et al.Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation[J].Cochrane Database Syst Rev,2005,Jan 25 (1):CD002249.
  • 3AL-Fadhli R,Sylvestre C,Buckett W,et al.A randomized trialof superovulation with two different doses of letrozole[J].Fertil Steril,2006,85 (1):161-164.
  • 4Holzer H,Casper R,Tulandi T.A new era in ovulation induction[J].Fertil Steril,2006,85 (2):277-284.

共引文献35

同被引文献30

  • 1任小青,苏胜红.腹腔镜手术治疗难治性多囊卵巢综合征不孕的临床研究[J].广西医科大学学报,2010,27(5):702-703. 被引量：6
  • 2Robert F, Casper MD, Letrozole. Ovulation or supper ovulation?[J]. Fertility and Sterility, 2003,80(6) : 1335.
  • 3曹泽毅.中华妇产科学[M].北京：人民卫生出版社,1999.2129.
  • 4Holzer H, Casper R, Tulandi T. A new era in ovulation induc- tion [J] . Fenil Steril, 2006, 85 (2): 277.
  • 5Robert F, Casper RF. Letrozole: ovulation or supperovulation [J] . Feril Steril, 2003, 80 (6) : 1335.
  • 6Sohrabvan F, Ansari SH, Bagheri M. Efficacy of combined metformin- letrozole in comparison with metformin -clomi- phene citrate in clomiphene resistant infertile women with poly- cystic ovarian disease [ J ] . Hum Reprod, 2006, 21 (6) : 1432.
  • 7Bayram N, Van Wely M, Kaaijk EM et al. Using an electro- cautery strategy or recombinant follicle stimulating hormone to induce ovulation in polycystic ovary syndrome: randomised controlled trial [J] . Br Med J, 2004, 328 (7433) : 192.
  • 8丁家怡.来曲唑与克罗米酚用于多囊卵巢综合征60例促排卵疗效比较[J].南通大学学报（医学版）,2007,27(6):521-522. 被引量：4
  • 9Thessaloniki ESHRE/ASRM-sponsored PCOS consensus workshop group. Consensus on infertility treatment related to polyeystie ovary syndrome[J]. Hum Reprod ,2008,23(3) :462 -477.
  • 10Mitwally F M,Casper R F. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate[J]. Fertil Steri1,2001,75(2) : 305-309.

引证文献3

二级引证文献21

现代医药卫生
2008年 第21期

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