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膀胱尿路上皮癌中VEGF、DC的表达及其临床意义 被引量：2

The expression and clinical significance of VEGF and DC in urothelial carcinoma
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摘要 目的:探讨血管内皮生长因子(VEGF)及树突状细胞(DC)在膀胱尿路上皮癌(UC)组织中的表达及其临床意义。方法:采用免疫组织化学EliVision二步法检测49例UC患者病理组织中VEGF蛋白及S100蛋白标记DC的表达情况,并以8例癌旁正常组织作为对照。结果:VEGF阳性组织DC计数为(8.35±3.25)个,阴性组织计数为(13.75±4.56)个;VEGF表达阳性的癌组织内,DC数目明显减少(P<0.05)。结论:VEGF和DC在UC组织中的表达具有负相关性,VEGF可能通过对DC的抑制途径,帮助UC逃避机体的肿瘤免疫反应。 Objective：To investigate the expression and clinical significance of vascular endothelial growth factor（VEGF）and Dendritic cells（DC） in urothelial carcinoma （UC）. Methods： Detect VEGF protein and S-100 protein marked DC in 49 UC specimens with EliVision^2 of immunohistochemistry, and contrasted with 8 tumor aside normal tissue specimens. Result： The count of DC in VEGF（＋） group is 8.35±3.25, and 13.75±4.56 in VEGF （-） group. The count of DC is obviously decreased in the VEGF（±） group. Conclusions： VEGF and DC are inverse correlation in UC. And it is possible that VEGF was helpful for UC to escape the tumor immunity by DC inhibition.
作者 戴庆 于永纲 李学德 崔斐 张慧明
机构地区 解放军第 南方医科大学附属南方医院肿瘤中心
出处 《临床泌尿外科杂志》 2008年第4期268-270,273,共4页 Journal of Clinical Urology
关键词 膀胱尿路上皮癌 血管内皮生长因子 树突状细胞 免疫组织化学 Urothelial carcinoma Tumor marker Immunohistochemistry
分类号 R737.14 [医药卫生—肿瘤]
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参考文献9

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二级参考文献10

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临床泌尿外科杂志
2008年 第4期

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