摘要
目的探讨P53、P16、TGF-α、EGFR、VEGF在膀胱移行细胞癌组织中的表达及意义。方法采用免疫组化法,对膀胱移行细胞癌P53、P16、TGF-α、EGFR、VEGF表达、缺失及生物学意义进行了研究。结果60例膀胱移行细胞癌患者中有68.3%(41/60)TGF-α阳性表达,EGFR阳性表达率35%(21/60),VEGF阳性表达率50%(30/60),P53阳性表达率38.3%(23/60),P16阳性表达率30%(18/60)。结论P16阳性表达率与患者的性别无明显相关性、随肿瘤分级和分期增高而降低,而P53、P16、TGF-α、EGFR、VEGF的表达率随肿瘤分级、分期的升高而明显增高,并且多个基因的共同表达也随着肿瘤分级、分期的升高而明显增高。
Objective To explore the expression and significance of P53, P16, transforming growth factor- a （TGF- α ）, epidermal growth factor （EGFR） and vascular endothelial growth factor （VEGF） in bladder transitional cell carcinoma （BTCC）. Methods Immunohistochemistry method was used to study the expression, deletion and significance of P53, P16, TGF-α , EGFR and VEGF. Results The positive expression rates of P53, P16, TGF-α , EGFR and VEGF in 60 cases of BTCC were 38.3%（23/60）, 30%（18/60）, 68.3%（41/60）, 35%（21/60） and 50%（30/60） respectively. Conclusion There was no significant association between the positive expression of P16 and gender, the pathologic grades and clinical stages （P〉0.05）. With the tumor pathologic grades and clinical stages increasing, the positive expression rates of P53, P16, TGF-α, EGFR and VEGF were also significantly higher, and their common expressions were increased.
出处
《现代泌尿外科杂志》
CAS
2007年第4期225-228,共4页
Journal of Modern Urology
