摘要
目的:研究羟丙基-β-环糊精在水溶液中对甲砜霉素的包合作用。方法:采用相溶解度法考察甲砜霉素与羟丙基-β-环糊精在水溶液中包合作用、包合比及包合过程中的热力学参数变化。结果:在不同温度(25℃、35℃、45℃)下,甲砜霉素的溶解度均随羟丙基-β-环糊精溶液浓度的增加而呈线性增加,相溶解度图为AL型。结论:在上述研究条件下,甲砜霉素与羟丙基--β环糊精可自发地形成摩尔比1:1的包合物。
Objective：To investigate the complexation of thiamphenicol with hydroxypropyl-β-cyclodextrin （HP-β-CD） in aqueous solutions. METHODS： The complexation of thiamphenicol with HP-β-CD, the inclusion molar ratio of host and vip molecules and thermodynamic parameters were detected using phase solubility method. RESULTS： The solubility of thiarnphenicol increased linearly with the increase of HP-β-CD level in aqueous solutions at different temperatures （25℃,35℃ and 45℃）,the phase solubility diagram was classified as type AL. CONCLUSIONS： Under the above research condition, the inclusion complexes of thiamphenicol with HP-β-CD can be formed spontaneously at a molar ratio of 1：1.
出处
《泰州职业技术学院学报》
2007年第6期44-46,49,共4页
Journal of Taizhou Polytechnic College
关键词
甲砜霉素
羟丙基-β-环糊
溶解度
包合物
thiamphenicol
hydroxypropyl-β-cyclodextrin
solubility
inclusion complex
