摘要
采用水溶液搅拌法制备甲砜霉素-羟丙基-β-环糊精包合物,通过正交试验优化工艺。得到包合反应最佳条件为:包合温度为50℃,包合时间为1 h,羟丙基-β-环糊精与甲砜霉素摩尔比为1∶1。并经X-线衍射、红外光谱分析法进行验证,证明甲砜霉素与羟丙基-β-环糊精已形成包合物。溶解度试验证明采用水溶液搅拌法形成包合物溶解度增大了约13倍,显著提高了甲砜霉素的溶解度。
Thiamphenicol - hydroxypropyl - β - cyclodextrin inclusion complex was prepared by electric stirring technique using orthogonal experiment technology. The optimum preparation proce- dure was the proportion of 1 ： 1 for HP - β - CD to Thiamphenicol, inclusion temperature at 50℃ for 1 hour. Its structure was proved by X- ray diffraction, IR, suggesting that the Thiamphenicol was wrapped by HP - β - CD. The solubility of Thiamphenicol in the inclusion complex was 13 times higher than that of pure Thiamphenicol, and its solubility increased significantly.
出处
《河北农业大学学报》
CAS
CSCD
北大核心
2009年第1期99-102,共4页
Journal of Hebei Agricultural University
关键词
甲砜霉素
羟丙基-Β-环糊精
包合物
正交试验
thiamphenicol
hydroxypropyl -β - cyclodextrin
inclusion complex
orthogonal experiment
