摘要
目的 研究重症肌无力（MG）患者的中枢疲劳对认知功能的影响。方法 对36例MG全身型病例与36例健康对照组进行认知量表检查,并在检查前后进行多成分疲劳量表评定,包括精神状态和体力疲劳评定,比较认知成绩与疲劳的关系。结果 全身型病例组与对照组比较,精神状态疲劳感变化显著[全身型病例组测验后精神状态疲劳评分为（3.99±1.04）分,对照组为（1.16±0.65）分,差异有显著性（P〈0.01）];且认知测验（包括CVLT、SDMT、连线测验2计时、延迟逻辑记忆、动物流畅性正确数）成绩与精神状态疲劳感的变化相关（P〈0.05）。结论 MG存在认知功能障碍,并与精神状态疲劳感相关。
Objective To ：study the fatigue and its impact on cognitive function of patients with myasthenia gravis. Methods Cognitive function of the 36 patients with the general myasthenia gravis were examined and the 36 control subjects with cognitive measures. All subjects completed the Multicomponent Fatigue Inventory （MFI） before examining . Then, the relation of cognitive performance and fatigue were analyzed. Results The ratings of change in mental fatigue of MG patients are significant higher than that in the control group（ the score of mental fatigue of the MG patients after testing is 3.99 ± 1.04, the score of the control group is 1.16 ± 0.65, P 〈 0.01 ）, several cognitive performance of the general MG patients were significantly related to the ratings of change in mental fatigue（ P 〈 0.05 ） . Conclusion There are disorder of cognitive function in the patients with myasthenia gravis and the cognitive performance is related to the changes of mental fatigue.
出处
《中国行为医学科学》
CSCD
2007年第3期217-219,共3页
Chinese Journal of Behavioral Medical Science
关键词
重症肌无力
认知成绩
中枢疲劳
Myasthenia gravis
Cognitive performance
Mental fatigue
