摘要
目的该研究旨在观察尼莫地平片对血管性认知损害的短期疗效。方法前瞻性开放性自身对照研究。64例神经内科门诊脑血管病患者,在常规二级预防药物的基础上,口服尼莫地平60～90 mg/d,12～24周。应用简明精神状态量表(mini mental state examination,MMSE)和北京版蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)作为认知评估工具,观察治疗前后患者认知功能的变化。结果三个月治疗后认知成绩总分显著高于治疗前,分别为:MMSE(26.3±2.7)vs(25.6±2.9),P=0.039;MoCA(20.5±4.6)vs(19.0±4.1),P=0.000,差异有显著性;治疗后MoCA的记忆分测验成绩显著高于治疗前,分别为(1.8±1.7)vs(1.1±1.2),P=0.000,差异有显著性。结论尼莫地平可有效地提高脑血管病患者的认知功能。
Objective To observe the efficacy of Nimodipine on vascular cognitive impairment in a shortperiod treatment. Methods It was a prospective opened own control study.Sixty-four patients with cerebrovascular disease were recruited from outpatient of neurology department.On the basis of secondary prevention drugs,patients were given to oral Nimodipine 60-90 mg/d.The patients' cognitive functions have been assessed using the mini mental state examination(MMSE) and Montreal cognitive assessment(MoCA) before and after 12-24 weeks treatment. Results After treatment of Nimodipine.the performance record were significantly better than before,total scores of MMSE were 26.3±2.7 vs 25.6±2.9(P=0.039),MoCA were 20.5±4.6 vs 19.0±4.1(P=0.000),and the memory test of MoCA were significant better than before(1.8±1.7 vs 1.1±1.2,P=0.000). Conclusion Nimodipine may have some benefits for cognitive function in patients with cerebral vascular disease.
出处
《中国卒中杂志》
2012年第10期781-785,共5页
Chinese Journal of Stroke
关键词
脑血管病
认知功能
尼莫地平
Cerebral vascular disease
Cognitive
Nimodipine
