摘要
８名健康男性志愿者交叉服用５００ｍｇ剂量的对乙酰氨基酚凝胶剂和片剂。血药浓度采用ＨＰＬＣ测定。对乙酰氨基酚凝胶剂的药动学参数：Ｔ１／２（Ｋａ）０．３０±０．２２ｈ，Ｔ１／２（Ｋｅ）２．１±０．４ｈ，Ｔｍａｘ１．０±０．４ｈ，Ｃｍａｘ５．１±１．５μｇ／ｍｌ，ＡＵＣ２１±５（μｇ／ｍｌ）·ｈ。这些参数与片剂的相似，凝胶剂相当于片剂的生物利用度为１０５．１％
A single 500mg oral dose of paracetamol gels and tablets were given to healthy 8 male volunteers in randomized self crossover study.Plasma concentrations of paracetamol were determined by HPLC.One compartment model with first order absorption was fit to the concentration time profiles of two formulations.Pharmacokinetic parameters of paracetamol gel were T 1/2Ka 0.30 ± 0.22 h, T 1/2Ke 2.1±0.4h, C max 5.1±1.5μg/ml, T max 1.0±0.4h, AUC 21±5μg/(ml·h).These were similar to the parameters of tabelets.Relative bioavailability of paracetamol gel was 105.1% compared with the tablet.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1997年第2期56-58,共3页
Chinese Journal of Hospital Pharmacy
