摘要
作者报道７例，平均年龄７１岁老年人，在围手术期，静脉滴注１．５ｇ头孢唑啉钠的药代动力学改变，得到各项药物动力学参数，并与５例６０岁以下组进行比较，得出老年组在分布相半衰期（ｔ１／２α））、消除相半衰期（ｔ１／２β）均显著延长，亦即在其分布及消除方面均较年轻组减慢（Ｐ＜０．０１）。研究结果表明，对老年人投药要掌握适量、适时、适度的原则。应用头孢唑啉钠１．５ｇ静脉滴注，８ｈ间隔血液谷浓度始终可维持在８μｇ／ｍｌ以上，１２ｈ间隔有近于半数超过８μｇ／ｍｌ，因此，两种用药间隔时间均可选用，但须考虑临床具体患者情况，老年人宜用等间隔投药，药量以每次１．５ｇ为适宜。
The changes of pharmacodynamics of cephazoline 1.5gm. iv, in a series of 7 patients with a mean age of 71 years old were studied perioperatively. All of the parameters of the results were compared with lhosein patients younger than 60 years. The distribution phase of half life of the agent (t 1/2 α) and the elimination phase of half of it (t 1/2 β) were significantly prolonged; namely its distribution and elimination were both lower than those in the younger patients.The gorge concentration in the blood with administration of cephazoline 1.5gm. iv. Q8hrs. was constantly maintained in 8 μg/ml or more; and proximal half of the results were exceed 8 μg/ml, when cephazoline administered 1.5gm iv. Q12hrs.Therefore, the principle of administration of such antibiotics must know well about the dose, times and limit properly. Both schemes could be selected in the elderly patients according to their general condition.
出处
《军医进修学院学报》
CAS
1997年第2期91-94,共4页
Academic Journal of Pla Postgraduate Medical School
