摘要
目的探讨凋亡基因Bcl-2、Bax与子宫肌瘤发生的关系。方法应用免疫组织化学S-P法检测40例子宫肌瘤(实验组)及子宫肌壁组织(对照组)中凋亡基因Bcl-2、Bax的表达。结果Bcl-2在子宫肌瘤组织中的阳性表达率(85%)明显高于子宫肌壁组织(27%),Bax在子宫肌瘤组织中的阳性表达率(17%)明显低于子宫肌壁组织(75%)。结论凋亡基因Bcl-2表达、Bax表达缺失与子宫肌瘤的发生有关。
Objective The purpose of this thesis is to investigate the relation between Bcl-2,Bax and the occurance of human uterine leiomyoma. Methods The expression of Bcl-2,Bax protein was employed to examine immunohistochemically in leiomyoma of the experiment group and adjacent normal myometrium of controling group. Results The expression of Bcl-2 protein in human u- terine was 85 % was significantly higher than that of adjacent nomal myometrium 27%. while the expressions of Pax protein was evidently lower in the former 17% that of latter 75 % in contrast. Conclusion The developping of human uterine leiomyoma was related to the expression of Bcl-2,the loss expression of Pax.
出处
《实用癌症杂志》
2005年第5期475-476,共2页
The Practical Journal of Cancer
