期刊文献+

脑苷激肽合并抗精神病药物治疗精神分裂症临床疗效观察 被引量:1

Study on Effect of Combining Cattle Encephalon Glycoside and Lgnotin Injection with Antimental Disorder Medication for Schizophrenia
在线阅读 下载PDF
导出
摘要 目的观察脑苷激肽合并抗精神病药物治疗精神分裂症的临床疗效观察。方法将80例精神分裂症患者随机分为两组,分别给予抗精神病药物合并脑苷激肽联合治疗(观察组),和单用抗精神病药物(对照组),治疗为8周。采用简表精神科量表(BPRS),阴性症状量表(SANS)定期进行评定。结果观察组总有效率为85%,对照组为70%,差异显著(χ2=3.66,P<0.05),两组(BPRS),(SANS)评分在第2周、第4周、第8周、差异均有显著性(P<0.01)。结论用脑苷激肽合并抗精神病药物治疗精神分裂症比单纯应用抗精神病药物疗效显著。 Objective To observe the effect of combining cattle encephalon glycoside and lgnotin injection with antimental disorder medicine for treating schizophrenia. Methods 80 patients with schizophrenia were divided randomly into two groups. Experimental group was given antimental disorder medicine with cattle encephalon glycoside and lgnotin Injection and control group was given antimental disorder medicine. The treatment had lasted for 8 weeks. During therapy time, brief psychiatric rating scale (BPRS) and SANS were adopted for evaluation. Results Efficiency rate of experimental group was 85% and that of control group was 72.5%. The difference is remarkable (X^2=3.66, P 〈 0.0 5). There were significant differences between two groups in the score of BPRS and SANS at second, third, eighth week of treatment (P 〈 0.01). Conclusions In treating schizophrenia, using cattle encephalon glycoside and lgnotin injection with antimental disorder medicine can get better effect than using antimental disorder medicine only.
出处 《神经疾病与精神卫生》 2005年第4期275-277,共3页 Journal of Neuroscience and Mental Health
关键词 精神分裂症 脑苷肌肽 病例对照研究 Schizophrenia Medicine therapy Cattle encephalon glycoside and lgnotin injection
  • 相关文献

参考文献10

  • 1陈彦方.中国精神障碍诊断与分类标准[M].济南:山东科学技术出版社,2001,4:56-66.
  • 2庞天鉴.DSM-Ⅳ分类与诊断标准[M].美国精神病学会杨森文库.西安:杨森出版局,2001,9:161-166.
  • 3张明圆.精神科评定量表手册[M].长沙:湖南科学技术出版社,1993.34-41.
  • 4Riehemann S,olz HP,tutzer P,t al,ypofrontality in neuroleptic - nauve schizophrenic patients during the Wisconsin Cardsorting Test - a f MRL study[J]. Eur Areh Psyehiatry Clin Neurosei,2001,241:66-71.
  • 5Cuesta MJ,eralta V. Cogrnitive disorders in the positive negative and disorganization syndromes of schizophrenia[J]. Sychiatry Res,1995,58:227-235.
  • 6Liddle PF,Friston KJ,Frigh CD,et al,Pattems of cerehral blood flow in schizophrenia[J]. Br J Psychiatry,1992,58:340-345.
  • 7舒畅,王高华,王惠玲,李洁,王得志.精神分裂症症状与威斯康星卡片分类测验成绩的相关性[J].中国心理卫生杂志,2004,18(8):580-582. 被引量:8
  • 8张大荣,王雪芹,李雪霓,汪毅,董问天,范征利,赵志宇,潘超,康兰.住院精神分裂症病人高血糖症的调查[J].中国心理卫生杂志,2004,18(8):572-575. 被引量:8
  • 9Newcomer JW. Haupt DW,ucetola R,t al. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia[J]. Arch Gen Psychiatry,2002,9:337- 345.
  • 10Dwyer DS,onohoe D,nducton of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake[J].Phamacol Biochem Behav,2003,5:255- 260.

二级参考文献25

  • 1Mukerjee S, Decina P, Bocola V, et al.. Diabetes mellitus in schizophrenic patients. Comp Psychiatry 1996; 37: 68-73.
  • 2Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry.2002; 59: 337 - 45.
  • 3Baymiller SP, Ball P, McMahon RP, Buchanan RW. Serum glucose and lipid changes during the course of clozapine treatment: the effect of concurrent beta- adrenergic antagonist treatment. Schizophr Res. 2003; 59:49 - 57.
  • 4Sernyak MJ, Gulanski B, Leslie DL, Rosenheck R. Undiagnosed hyperglycemia in clozapine- treated patients with schizophrenia. J Clin Psychiatry. 2003; 64: 605 - 8.
  • 5Melkersson KI, Dahl ML. Relationship between levels of insulin or triglycerides and serum concentrations of the atypical antipsychotics clozapine and olanzapine in patients on treatment with therapeutic doses. Psychopharmacology. 2003; 170: 157-66.
  • 6Henderson DC. Atypical antipsychotic- induced diabetes mellitus:how strong is the evidence? CNS Drugs. 2002; 16:77 - 89.
  • 7Lindenmayer JP, Czobor P, Volavka J, Citrome L, Sheitman B,McEvoy JP, Cooper TB, Chakos M, Lieberman JA. Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics. Am J Psychiatry. 2003;160: 2
  • 8Melkersson KI, Dahl ML. Relationship between levels of insulin or triglycerides and serum concentrations of the atypical antipsychotics clozapine and olanzapine in patients on treatment with therapeutic doses. Psychopharmacology. 2003; 170: 157-166.
  • 9Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G.. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry. 2002; 59: 337-345.
  • 10Dwyer DS, Donohoe D. Induction of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake. Pharmacol Biochem Behav. 2003; 75: 255 - 260.

共引文献333

同被引文献38

引证文献1

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部