摘要
用豚鼠作为动物模型,对肺螨病的病理进行了研究。结果证实了豚鼠用螨作人工感染之后,5天在其肺叶就可形成结节,40天后压片观察仍可见螨在结节内寄生,组织学病理研究发现,病鼠肺部病理变化的主要特征为细支气管炎和细支气管周围炎。结合螨的电镜扫描形态观察和动物肺组织病理变化,认为本病的致病机理分为两个过程:即螨机械性破坏肺组织引起的急性炎症反应(组织病理性改变)和变态反应导致的免疫病理过程。
The pathological study of pulmonary acariasis was maded by using the guinea pig as the animal model.The results confirm that the tuberdes will be formed in the lobes of lungs in five days after making artificial infections on guinea pigs, and the acariasis'parasitism can still be seen in tudercles after forty days through the observation of the slide. We've found that the main characteristics of the pathological change of the guinea pigs' lungs was bronchiolitis and peribronchiolitis through the pathological histological study. Concluding the EM morphologic observations of theacariasis and the pathological change of animals'lung tissue, we divided the pathogenic mechanism of this disease into two processes. The acute inflammation (tissue pathology change) caused by the acariasis destroying the lung tissue and the immunopathogical course caused by the allergic reaction.
出处
《齐齐哈尔医学院学报》
1991年第1期3-6,共4页
Journal of Qiqihar Medical University
关键词
医学实验动物模型
肺螨病
病理研究
The animal model for medical experiment
Pulmonary acaria-sis
Pathological study
