摘要
目的探讨轻创术后的子宫内膜病理性改变对体外受精-胚胎移植(1VF-ET)结局的影响。方法回顾性分析2007年1月至2009年6月在我院生殖中心行体外受精-胚胎移植(IVF-ET)治疗的不孕症患者,促性腺激素(Gn)启动日B超显示子宫内膜回声异常或内膜厚度>5 mm的患者共237例,其中行子宫内膜轻创术者220例为研究组,未行轻创术者17例为对照组,并根据诊刮后标本病检结果将研究组再分为正常月经期内膜组、分泌反应欠佳组和子宫内膜息肉组,比较各组患者临床妊娠率、胚胎种植率和活产率的差别。结果研究组患者临床妊娠率、胚胎种植率和活产率均显著高于对照组(P<0.05);诊刮后标本病检结果虽然各组间临床妊娠率及胚胎着床率无明显差异,但子宫内膜息肉患者的活产率明显低于月经期内膜组(P<0.05)。结论子宫内膜轻创术能显著提高IVF-ET周期临床妊娠率、胚胎种植率和活产率,子宫内膜异常的病理学改变是导致活产率低下的主要因素。
Objective. To analyze the effect of endometrial local injury on the incidence of successful pregnancy in patients undergoing in vitro fertilization-embryo transfer （IVF-ET）. Methods. A total of 237 patients with endometrial disorder or thickness diagnosed by ultrasound on the day of gonadotropin administration were studied. Two hundred and twenty patients （treatment group） were performed local injury to regain normal endometrium or removed thickened endometrium at the same day of gonadotropin administration. The remaining 17 patients were not treated as control group. The outcomes of IVF-ET in the two groups were evaluated by the rates of clinical pregnancy, embryo implantation and live births. Results： The rates of clinical pregnancy, embryo implantation and live births in the treatment group were significantly higher than those in the control group （P〈0.05）. The live birth rate in the endometrial polyp group according to the pathological result was significantly lower than that of the normal endometrial groups, though there were no significant differences in the rates of clinical pregnancy and embryo implantation between the two groups （P〈0.05）. Conclusions. The endometrial local injury significantly improved the successful pregnancy in patients undergoing in vitro fertilization. The abnormal endometrial pathological change was the main reason of lower live births.
出处
《生殖医学杂志》
CAS
2012年第1期17-20,共4页
Journal of Reproductive Medicine
关键词
体外受精-胚胎移植
子宫内膜
轻创术
妊娠结局
In vitro fertilization-embryo transfer
Endometrium
Local injury
Pregnancyoutcome
