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内皮素-1和C-反应蛋白对急性肺栓塞病情和预后的评估 被引量：4

Endothelin-1 and C-reactive Protein for the Evaluation of Severity and Prognosis of Acute Pulmonary Embolism
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摘要 [目的]探讨内皮素-1(endothelin-1,ET-1)和C-反应蛋白(c-reacting protein,CRP)水平对评估急性肺栓塞(acute pulmonary embolism,APE)患者病情和预后的价值.[方法]检测133例APE患者外周血血清ET-1和CRP水平,分析其与患者的严重程度、心功能不全及预后的相关性.[结果]血清ET-1、CRP水平和右心功能不全发生率随着APE患者病情严重程度的增加而明显增加(P<0.05),同时血清ET-1水平与CRP水平呈显著正相关(r=0.623,P<0.01);APE患者动脉血氧分压(PaO2)与血清ET-1和CRP水平呈显著负相关(r=-0.690,-0.579,P<0.01);APE患者右心室扩大与血清 ET-1水平呈显著正相关(r=0.591,P<0.01),肺动脉高压与血清ET-1和 CRP水平呈显著正相关(r=0.702,0.566,P<0.01);预后良好组ET-1、CRP、PaO2和二氧化碳分压(PaCO2)明显优于预后不良组(P<0.05).[结论]ET-1和CRP能很好评估APE患者疾病的严重性及预测其临床转归,并指导治疗.
作者 李龙学
机构地区 中山大学附属第六医院呼吸内科
出处 《医学临床研究》 CAS 2012年第6期-,共3页 Journal of Clinical Research
关键词 肺栓塞 急性病 内皮缩血管肽类 C反应蛋白质 预后
分类号 R563.5 [医药卫生—呼吸系统]
  • 相关文献

参考文献12

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二级参考文献66

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共引文献35

同被引文献41

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引证文献4

二级引证文献61

医学临床研究
2012年 第6期

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