摘要
目的:探讨过敏性紫癜(HSP)患儿血清和尿液中黏附分子表达水平及意义。方法:HSP患儿67例,其中无肾损伤37例(NO-HSPN组),有肾损伤30例(HSPN组),正常对照组20例,采用ELISA法检测血清和尿液中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)的水平。常规方法检测24h尿蛋白定量。结果:3组血清sICAM-1、sVCAM-1水平差异均无统计学意义(F=2.017和1.408,P均>0.05),尿液水平差异均有统计学意义(F=41.613和14.425,P均<0.05)。NO-HSPN组和HSPN组尿液sICAM-1水平均明显高于正常对照组(P<0.05),但NO-HSPN组和HSPN组之间差异无统计学意义(P>0.05);尿液sVCAM-1水平在HSPN组较NO-HSPN组和正常对照组均明显增高(P<0.05)。HSPN组尿液sVCAM-1水平与24h尿蛋白定量呈正相关(r=0.625,P=0.003)。结论:HSPN患儿尿液sICAM-1和sVCAM-1水平增高,其中尿液sVCAM-1可以用于肾脏免疫炎性损伤的评价。
Aim： To study the serum and urine levels of adhesion molecules of children with Henoch-schonlein purpura （ HSP） . Methods： A total of 37 children with HSP but not HSP nephritis （ NO-HSPN group） ,30 children with HSP ne-phritis （ HSPN group） ,and 20 normal control（ normal group） were subjected to measure the levels of soluble intercellular adhesion molecule-1（ sICAM-1） and soluble vascular cellular adhesion molecule-1（ sVCAM-1） in the serum and urine u-sing ELISA. 24 h urine protein was measured by conventional method. Results： In the three groups,there were significant differences in the urinary levels of sICAM-1 and sVCAM-1（ F = 41. 613 and 14. 425,P 0. 05） . The urine levels of sI-CAM-1 in NO-HSPN group and HSPN group were higher than that in normal group（ P 0. 05） . Urinary sVCAM-1 in HSPN group was higher than those in NO-HSPN group and normal group（ P 0. 05） . In HSPN group,the level of urinary sV-CAM-1 was positively correlated with 24 h urine protein （ r = 0. 625,P = 0. 003） . Conclusion： The levels of urinary sI-CAM-1 and sVCAM-1 are enhanced in children with HSPN,and the level of urinary sVCAM-1 may be used to assess the degree of the immune inflammation of kidney.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2013年第2期179-181,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省科技厅科学发展计划基金资助项目0611044100
河南中医学院科技创新人才支持计划基金资助项目
