摘要
目的观察噻托溴胺联合沙美特罗/氟替卡松治疗慢性阻塞性肺疾病的临床疗效,并分析其对肺功能、血气指标的影响。方法选取2018年3月—2020年1月广元市中心医院收治的慢性阻塞性肺疾病患者70例,随机分为对照组与试验组,每组35例。对照组患者给予沙美特罗/氟替卡松治疗,试验组患者在对照组基础上加用噻托溴铵治疗,两组患者均连续治疗12周。比较两组患者临床疗效,治疗前后肺功能指标[包括第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值的百分比(FEV1%)及用力肺活量(FVC)]及血气分析指标[包括动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)及动脉血氧饱和度(SaO2)]。结果(1)治疗后,试验组患者总有效率为97.1%(34/35),高于对照组的82.9%(29/35)(P<0.05)。(2)治疗前两组患者FEV1、FEV1%及FVC比较,差异无统计学意义(P>0.05);治疗后试验组患者FEV1和FVC大于对照组,FEV1%高于对照组(P<0.05)。(3)治疗前两组患者PaO2、PaCO2及SaO2比较,差异无统计学意义(P>0.05);治疗后试验组患者PaO2、SaO2高于对照组,PaCO2低于对照组(P<0.05)。结论噻托溴铵联合沙美特罗/氟替卡松具有药物协同治疗作用,可有效提高慢性阻塞性肺疾病患者临床疗效,改善肺功能及血气分析。
Objective To observe clinical efficacy of tiotropium bromide combined with salmeterol/fluticasone in the treatment of copd and its influence on pulmonary function and blood gas indexes.Methods From March 2018 to January 2020,a total of 70 patients with COPD were selected in Guangyuan Central Hospital,and they were randomly divided into control group(n=35)and experimental group(n=35).The control group was treated with salmeterol/fluticasone,and the experimental group was treated with tiotropium bromide on the basis of the control group,both groups were treated for 12 weeks.The clinical efficacy,pulmonary function indexes(including FEV1%,FEV1%and FVC)and blood gas analysis indexes(including PaO2,PaCO2 and SaO2)were compared between the two groups before and after treatment.Results(1)After treatment,the total effective rate of the experimental group was 97.1%(34/35),which was higher than 82.9%(29/35)of the control group(P<0.05).(2)There was no significant difference in FEV1,FEV1%and FVC between the two groups before treatment(P>0.05);after treatment,FEV1 and FVC of the experimental group were greater than those of the control group,and FEV1%was higher than that of the control group(P<0.05).(3)There was no significant difference in PaO2,PaCO2 and SaO2 between the two groups before treatment(P>0.05);after treatment,PaO2 and SaO2 of the experimental group were higher than those of the control group,while PaCO2 was lower than that of the control group(P<0.05).Conclusion Tiotropium bromide combined with salmeterol/fluticasone has drug synergistic effect,which can effectively improve the clinical efficacy,pulmonary function and blood gas analysis.
作者
伏籽桥
文晓蛟
FU Ziqiao;WEN Xiaojiao(Department of Respiratory and Critical Care Medicine,Guangyuan Central Hospital,Guangyuan 628000,China;Department of Otolaryngology,Head and Neck Surgery,Guangyuan Central Hospital,Guangyuan 628000,China)
出处
《实用心脑肺血管病杂志》
2020年第S01期63-65,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
慢性阻塞性肺疾病
噻托溴铵
沙美特罗/氟替卡松
肺功能
血气指标
Chronic obstructive pulmonary disease
Tiotropium bromide
Salmeterol/fluticasone
Pulmonary function
Blood gas index
