摘要
目的分析中西医结合治疗对支气管哮喘患者的疗效、免疫功能及肺功能水平的影响。方法支气管哮喘患者102例按照随机分组法分为西医组(n=51)和中西医组(n=51)。西医组仅以常规西医治疗,中西医组在此基础上结合中药汤剂治疗。2组以2周为1个治疗疗程,连续治疗2个疗程。比较治疗疗效,治疗前后免疫功能指标变化,治疗前后肺功能指标1秒用力呼出量(forced expiratory volume of 1 second,FEV1)、用力肺活量(forced vital capacity,FVC)、呼吸峰流速(peak expiratory folw,PEF)变化及治疗期间用药安全性。结果中西医组总有效率(94.12%)明显高于对照组(72.55%),2组比较有统计学意义(P<0.05);2组CD3^+、CD4^+以及CD4^+/CD8^+治疗后明显增加(P<0.05),而CD8^+治疗后明显下降(P<0.05),中西医组CD3^+、CD4^+以及CD4^+/CD8^+治疗后高于对照组(P<0.05),而CD8^+治疗后低于对照组(P<0.05);2组FEV1、FVC以及PEF水平治疗后均明显上升(P<0.05),中西医组FEV1、FVC以及PEF水平高于西医组(P<0.05);2组患者不良反应发生率比较无统计学意义(P>0.05)。结论中西医结合治疗支气管哮喘可明显改善患者免疫功能和肺功能,且安全性良好。
Objective To investigate the clinical efficacy of integrated traditional Chinese and western medicines in the treatment of the patients with bronchial asthma and the effect on the levels of immune function and pulmonary function. Methods 102 cases of patients with bronchial asthma were randomly divided into the western medicine group （n = 51） and the traditional Chinese and western medicine group （n = 51）. The western medicine group were treated with conventional western medicine and the the traditional Chinese and western medicine group were treated with Chinese medicine on the basis of the treatment of the western medicine group. For one weeks as a course, and both group were treated continuously for two course. To make a comparison of the efficacy, the changes of the immune function index before and after treatment, the changes of Forced expiratory volume of one second, the forced vital capacity and the Peak expiratory folw in before and after treatmant and the safely evaluation during the treatment with both groups. Results The total effective rate in the traditional Chinese and western medicine group （94.12%） were significantly higher than that of the western medicine group （72.55%）, there was statistical significance between the two groups （P 〈 0.05）; After treatment, the CD3^＋, CD4^＋ and CD4^＋/CD8^＋ in both groups were significantly increased than that of the before （P 〈 0.05）, while the CD8^＋ were significantly decline （P 〈 0.05）; The CD3^＋, CD4^＋ and CD4^＋/ CD8^＋ in CWM group were significantly higher than that of the the traditional Chinese and western medicine group （P 〈 0.05）, while the CD8^＋ were significantly lower than that of the western medicine group （P〈0.05）; The FEV1, FVC and PEF in both groups were significantly higher than that of the before （P〈0.05）; The FEV1, FVC and PEF in the traditional Chinese and western medicine group were significantly higher than that of the western medicine group （P〈0.05）; There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）. Conclusion The treatment of bronchial asthma with combination of traditional Chinese and western medicine can obviously improve the immune function and lung function of the patients, and the safety is good.
作者
成青
张云凤
周奇兴
CHENG Qing;ZHANG Yunfeng;ZHOU Qixing(Respiratory Department,Li Qun Hospital in Putuo District,Tongji University School of Medicine,Shanghai Putuo District,Shanghai 200333,Chin)
出处
《吉林中医药》
2018年第7期782-785,共4页
Jilin Journal of Chinese Medicine
基金
上海市普陀区科委卫生系统自主创新科研基金项目(KW-2017-03)
关键词
支气管哮喘
免疫功能
肺功能
发汗散寒
宣肺解表
和营养血
敛肺止咳
bronchial asthma
immune function
pulmonary function
induces sweating and dissipating cold
diffuse the lung and resolve the exterior
harmonizing nutrient and nourish the blood
constrain the lung and suppress cough
