摘要
目的 探讨清肺汤+西医抗感染药物治疗老年慢性肺炎的临床效果及安全性。方法 选取2018年1月—2021年3月枣庄市中医医院收治的88例老年慢性肺炎患者为研究对象,依据治疗方法不同分为两组,各44例。对照组采用西医抗感染治疗,研究组采用清肺汤联合西医抗感染药物治疗。比较两组的治疗总有效率、疾病复发率、肺功能指标水平(最大呼气峰流速、最大通气量、肺活量)、炎症反应相关因子水平(C反应蛋白、白细胞介素-6、血清内酯素)以及不良反应发生情况。结果研究组治疗总有效率为95.45%(42/44),高于对照组的75.00%(33/44),差异有统计学意义(χ^(2)=7.310,P<0.05)。研究组复发率低于对照组,差异有统计学意义(P<0.05)。治疗后研究组最大呼气峰流速、最大通气量、肺活量水平均高于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组C反应蛋白、白细胞介素-6、血清内酯素水平均低于对照组,差异有统计学意义(P均<0.05)。治疗期间,两组均未出现严重不良反应。结论 清肺汤与西医抗感染药物联合应用治疗老年慢性肺炎,可增强治疗效果,降低疾病复发率,明显改善炎症反应和肺功能,具有较高安全性。
Objective To explore the clinical effects and safety of Qingfei Decoction + Western antiinfective drugs in the treatment of elderly patients with chronic pneumonia.Methods Eighty-eight cases of elderly patients with chronic pneumonia admitted to Zaozhuang Hospital of Traditional Chinese Medicine from January 2018 to March 2021 were selected as the study subjects,and were divided into two groups of 44 cases each based on different treatment methods.The control group was treated with Western anti-infection therapy,and the study group was treated with Qingfei Decoction combined with Western anti-infective drugs.The two groups were compared in terms of total effective rate of treatment,disease recurrence rate,level of lung function indexes(maximal peak expiratory flow rate,maximal ventilation,lung capacity),level of inflammatory responserelated factors(C-reactive protein,interleukin-6,serum endostatin),and the occurrence of adverse reactions.Results The total effective rate of treatment in the study group was 95.45%(42/44),which was higher than 75.00%(33/44) in the control group,and the difference was statistically significant(χ^(2)=7.310,P<0.05).The recurrence rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).After Treatment,the levels of maximal peak expiratory flow rate,maximal ventilation,and lung capactity were higher in the study group than in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of C-reactive protein,interleukin-6 and serum lactone in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).During the treatment,there were no serious adverse reactions in the two groups.Conclusion The combined application of Qingfei Decoction and Western anti-infective drugs can enhance the therapeutic effect of Elderly patients with chronic pneumonia,reduce the recurrence rate of the disease,improve the inflammatory response and lung function,with a high degree of safety.
作者
褚福娟
刘丽萍
王祥领
CHU Fujuan;LIU Liping;WANG Xiangling(Department of Pharmacy,Zaozhuang Hospital of Traditional Chinese Medicine,Zaozhuang 277000,Shandong,China)
出处
《世界复合医学》
2024年第5期18-21,共4页
World Journal of Complex Medicine
关键词
清肺汤
西医抗感染药物
老年慢性肺炎
炎症反应
安全性
Qingfei Decoction
Western anti-infective drugs
Chronic pneumonia in the elderly
Inflammatory response
Safety
