摘要
线粒体自噬是为了保证线粒体的质量及细胞内部稳态,而进行的选择性清除细胞中损伤线粒体的一种方式,它广泛参与到多种疾病病理变化的过程中,研究指出,动脉粥样硬化(atherosclerosis, AS)的主要病变与抗氧化应激障碍、炎症反应、细胞凋亡等密不可分,线粒体自噬障碍可一定程度加重AS的进程。中医认为AS的出现与脾失健运,痰瘀互结密切相关,线粒体自噬这种清除损伤线粒体的方法与中医的祛痰化瘀理论相一致。从中、西医不同角度,结合国内外的文献研究,探讨健脾祛痰化瘀的中医治法与线粒体自噬在AS中的治疗作用。
Mitophagy is a way of selectively removing damaged mitochondria in cells to ensure the quality of mitochondria and the homeostasis of cells. It is widely involved in the pathological changes of a variety of diseases. Studies have pointed out that the main lesions of Atherosclerosis(AS) are closely related to antioxidant stress disorder, inflammatory response, apoptosis, etc., and mitophagy disorder can aggravate the process of AS to a certain extent. According to traditional Chinese medicine, the occurrence of AS is closely related to the impaired movement of the spleen and the interaction of phlegm and blood stasis. The method of removing damaged mitochondria by mitophagy is consistent with the theory of removing phlegm and removing blood stasis in traditional Chinese medicine. Therefore, this paper, from different perspectives of Chinese and western medicine, combined with domestic and foreign literature research, discusses the role of traditional Chinese medicine therapy in invigorating the spleen, removing phlegm and removing stasis and mitophagy in the treatment of AS.
作者
佟惊宇
姜钧文
孔德昭
张妮
TONG Jingyu;JIANG Junwen;KONG Dezhao;ZHANG Ni(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《实用中医内科杂志》
2023年第2期46-49,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
辽宁省科学技术基金项目(2019-zd-0438)
关键词
动脉粥样硬化
线粒体自噬
健脾
祛痰
化瘀
中医药
atherosclerosis
mitophagy
Jianpi
Qutan
Huayu
traditional Chinese medicine
