目的深入分析婴儿胆汁淤积性肝病(ICH)领域的研究现状、热点和前沿趋势,以期为该领域未来的发展提供参考。方法采用文献计量学方法,检索中国知网和Web of Science数据库2004-2023年发表的ICH相关文献。利用Excel 2021统计分析文献的年...目的深入分析婴儿胆汁淤积性肝病(ICH)领域的研究现状、热点和前沿趋势,以期为该领域未来的发展提供参考。方法采用文献计量学方法,检索中国知网和Web of Science数据库2004-2023年发表的ICH相关文献。利用Excel 2021统计分析文献的年发文量、发表国家、作者。用VOSviewer 1.6.13软件构建国家、作者合作关系图和关键词共现聚类图,用R(4.3.1版)Bibliometrix包(3.13版)绘制年度热点变化趋势图。结果共纳入中文文献666篇,英文文献1812篇,发文量整体呈上升趋势。美国、中国、英国为发文量排名前三的国家。中文文献倾向于ICH的感染因素和药物治疗,英文文献则更关注遗传学分析、综合治疗策略和疾病预后。遗传学研究、个性化营养管理,创新的基因诊断技术或将成为未来研究的趋势。结论美国在ICH研究中处于领先地位。中、英文文献虽有共性,但在侧重点上存在差异。未来研究应重点关注遗传学机制、个性化营养管理和基因诊断技术。展开更多
Background: Malnutrition, a serious public health concern, is influenced by various factors. Objective: The study aims to explore malnutrition issues among infants under five years old in Guéra Province. Methods:...Background: Malnutrition, a serious public health concern, is influenced by various factors. Objective: The study aims to explore malnutrition issues among infants under five years old in Guéra Province. Methods: The study used a cross-sectional design and a two-stage cluster sampling method to select participants. The study population was infants aged between 0 - 24 months. Data collection was done between June 2023 and September 2024;it included anthropometric measurements, blood analyses, and interviews. Anthropometric parameters were calculated using ENA for SMART software. Statistical analyses were performed by R Studio to investigate associations between different characteristics, using logistic regression models to identify risk factors. A p-value less than 0.05 was considered significant. Results: The study included 377 infants in eight villages in Guéra Province, Chad. The sample was predominantly girls (55.3%), with a median age of 16 months. Most infants (94%) were mixed-fed, and only 6% were exclusively breastfed. We found that 7.3% of children were globally malnourished, with higher rates in boys 9.6%. A significant disparity existed between boys and girls in global acute malnutrition (GAM) rates, with boys having a higher prevalence of 17.9%. A substantial proportion of Infants were underweight, with males 27.4%. Stunting was prevalent 20.1%. Several factors were associated with malnutrition, including gender, feeding practices, infectious diseases, and socioeconomic factors. Diarrhea, malaria, limited access to drinking water, and early diet diversification were significantly associated with malnutrition. Conclusion: Targeted interventions are necessary to address these issues and improve the nutritional status of children in the Guéra province.展开更多
Cronobacter spp.has strong resistance to desiccation and high permeability in Enterobacteriaceae,and powdered infant formula(PIF)is one of the main contamination routes.In recent years,the contamination of Cronobacter...Cronobacter spp.has strong resistance to desiccation and high permeability in Enterobacteriaceae,and powdered infant formula(PIF)is one of the main contamination routes.In recent years,the contamination of Cronobacter spp.in PIF incidents occurs from time to time,causing infant serious diseases or death.In this investigation,matrix-assisted laser desorption/ionization time of flight mass spectrometry was used to identify the phenotypes of 35 Cronobacter strains isolated from PIF and its processing environment.Subsequently,the isolates were evaluated for drying and osmotic pressure tolerance.The results showed that the deactivation rate of the strains ranged from 9.01%to 77.57%,and the highest osmotic pressure condition the strains could tolerate was 6 g/100 mL Na Cl.In addition,there was a positive correlation between biofilm formation ability and desiccation resistance.Combined with transcriptomics,Cronobacter spp.could activate biofilm synthesis,produce more trehalose,accumulate betaine and electrolytes to stabilize intracellular structure under the two treatment conditions.A total of 31 and 43 genes were found related to desiccation and permeability resistance,respectively.And some genes(cysM,thuF,ycjO,etc.)were found to be associated with two tolerances for the first time.展开更多
文摘目的深入分析婴儿胆汁淤积性肝病(ICH)领域的研究现状、热点和前沿趋势,以期为该领域未来的发展提供参考。方法采用文献计量学方法,检索中国知网和Web of Science数据库2004-2023年发表的ICH相关文献。利用Excel 2021统计分析文献的年发文量、发表国家、作者。用VOSviewer 1.6.13软件构建国家、作者合作关系图和关键词共现聚类图,用R(4.3.1版)Bibliometrix包(3.13版)绘制年度热点变化趋势图。结果共纳入中文文献666篇,英文文献1812篇,发文量整体呈上升趋势。美国、中国、英国为发文量排名前三的国家。中文文献倾向于ICH的感染因素和药物治疗,英文文献则更关注遗传学分析、综合治疗策略和疾病预后。遗传学研究、个性化营养管理,创新的基因诊断技术或将成为未来研究的趋势。结论美国在ICH研究中处于领先地位。中、英文文献虽有共性,但在侧重点上存在差异。未来研究应重点关注遗传学机制、个性化营养管理和基因诊断技术。
文摘Background: Malnutrition, a serious public health concern, is influenced by various factors. Objective: The study aims to explore malnutrition issues among infants under five years old in Guéra Province. Methods: The study used a cross-sectional design and a two-stage cluster sampling method to select participants. The study population was infants aged between 0 - 24 months. Data collection was done between June 2023 and September 2024;it included anthropometric measurements, blood analyses, and interviews. Anthropometric parameters were calculated using ENA for SMART software. Statistical analyses were performed by R Studio to investigate associations between different characteristics, using logistic regression models to identify risk factors. A p-value less than 0.05 was considered significant. Results: The study included 377 infants in eight villages in Guéra Province, Chad. The sample was predominantly girls (55.3%), with a median age of 16 months. Most infants (94%) were mixed-fed, and only 6% were exclusively breastfed. We found that 7.3% of children were globally malnourished, with higher rates in boys 9.6%. A significant disparity existed between boys and girls in global acute malnutrition (GAM) rates, with boys having a higher prevalence of 17.9%. A substantial proportion of Infants were underweight, with males 27.4%. Stunting was prevalent 20.1%. Several factors were associated with malnutrition, including gender, feeding practices, infectious diseases, and socioeconomic factors. Diarrhea, malaria, limited access to drinking water, and early diet diversification were significantly associated with malnutrition. Conclusion: Targeted interventions are necessary to address these issues and improve the nutritional status of children in the Guéra province.
基金supported by the Joint Funds of the National Natural Science Foundation of China(U21A20272)。
文摘Cronobacter spp.has strong resistance to desiccation and high permeability in Enterobacteriaceae,and powdered infant formula(PIF)is one of the main contamination routes.In recent years,the contamination of Cronobacter spp.in PIF incidents occurs from time to time,causing infant serious diseases or death.In this investigation,matrix-assisted laser desorption/ionization time of flight mass spectrometry was used to identify the phenotypes of 35 Cronobacter strains isolated from PIF and its processing environment.Subsequently,the isolates were evaluated for drying and osmotic pressure tolerance.The results showed that the deactivation rate of the strains ranged from 9.01%to 77.57%,and the highest osmotic pressure condition the strains could tolerate was 6 g/100 mL Na Cl.In addition,there was a positive correlation between biofilm formation ability and desiccation resistance.Combined with transcriptomics,Cronobacter spp.could activate biofilm synthesis,produce more trehalose,accumulate betaine and electrolytes to stabilize intracellular structure under the two treatment conditions.A total of 31 and 43 genes were found related to desiccation and permeability resistance,respectively.And some genes(cysM,thuF,ycjO,etc.)were found to be associated with two tolerances for the first time.
