摘要
1例耐碳青霉烯-替加环素肺炎克雷伯菌致多系统感染的4月龄婴儿,最初使用多种抗菌药物(美罗培南、万古霉素、替加环素)联合治疗效果不佳,临床药师依据其病理生理特点、辅助检查结果、药物的药代动力学/药效学特点,给予头孢他啶/阿维巴坦联合多黏菌素B静滴抗感染,并进行治疗药物监测,最终患儿治愈出院,治疗期间未发生药物不良反应。
A 4-month-old infant with multiple system infections caused by carbapenem tigecycline resistant Klebsiella pneumoniae was initially treated with a combination of multiple antibiotics(meropenem,vancomycin,tigecycline),but the effect was not satisfactory.Based on its pathological and physiological characteristics,auxiliary examination results,and pharmacokinetic/pharmacodynamic characteristics of drugs,the clinical pharmacists suggested ceftazidime/avibactam combined with polymyxin B intravenous infusion for anti-infection treatment,and monitored the therapeutic drugs.The child was eventually cured and discharged without any adverse drug reactions during the treatment period.
作者
洪文英
黄亮
HONG Wenying;HUANG Liang(Department of Pharmacy,Wenjiang District People’s Hospital,Chengdu 611130,China;Department of Pharmacy,West China Second Hospital,Sichuan University,Chengdu 610011,China)
出处
《药学与临床研究》
2025年第1期75-77,共3页
Pharmaceutical and Clinical Research
