Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In a...Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In addition to repressing the transcription of multiple clock genes associated with circadian rhythms,NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes,including autophagy,immunity,inflammation,metabolism,and aging in multiple organs.This review focuses on the pivotal role of NR1D1 as a key transcription factor in the gene regulatory network,with particular emphasis on the milestones of the latest discoveries of NR1D1 ligands.NR1D1 is considered as a promising drug target for treating diverse diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related diseases.Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application in many organ injury-related disorders.展开更多
基金supported by the National Natural Science Foundation of China(82070422,82200330)the China Postdoctoral Science Foundation(2023T160526 and 2022M722571)+2 种基金the Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053)the High-end Foreign Expert Introduction Program of National Science and Technology(G2022040014L)the Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).
文摘Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In addition to repressing the transcription of multiple clock genes associated with circadian rhythms,NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes,including autophagy,immunity,inflammation,metabolism,and aging in multiple organs.This review focuses on the pivotal role of NR1D1 as a key transcription factor in the gene regulatory network,with particular emphasis on the milestones of the latest discoveries of NR1D1 ligands.NR1D1 is considered as a promising drug target for treating diverse diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related diseases.Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application in many organ injury-related disorders.
