摘要
核酸疫苗 (DNA疫苗 )是 2 0世纪 90年代诞生的一种新型疫苗 ,具有能够激发机体全面免疫反应、不散毒、便于储存和运输等优点。抗原递呈细胞在 DNA疫苗诱导产生的 CTL反应中起主导作用。 DNA疫苗的运输载体 (脂质体、减毒突变的胞内菌等 )、佐剂 (细胞因子等 )以及疫苗接种方法和途径等因素可以提高和改变 DNA疫苗的免疫效果与反应类型。 DNA疫苗自诞生以来 ,其安全性一直是人们关心的问题 ,也是 DNA疫苗得以日后应用于临床的关键。
DNA vaccine, a new type vaccine emerging in 1990's, can induce complete immune response without infectiousness and with easy storage and transportation. Antigen-presenting cells (APCs) play a leading role in cytotoxic T lymphocyte (CTL) activity. The delivery carriers of DNA vaccine (liposomes, attenuated organisms), genetic adjuvants (cytokines) and delivery methods and routes of delivery for plasmid DNA are able to improve immune efficacy and change response types. The safety of DNA vaccine concerned since its appearance will be critical for the future clinical use of DNA vaccine.
出处
《动物医学进展》
CSCD
2004年第3期37-40,共4页
Progress In Veterinary Medicine
