摘要
AIM: To investigate the expression of 1A6 gene in the lesionsduring the development of intestinal gastric carcinoma.METHODS: One hundred and thirty-six cases of intestinalmetaplasia (IM) from surgical resections and biopsy wereclassified by mucous staining. Expression of 1A6 in all caseswas detected using immunohistochemical S-P method.RESULTS: The positive rates of 1A6in normal and superficialgastritis (SG), severe atrophic gastritis (SAG), type Ⅰ, Ⅱ, ⅢIM, dysplasia (Dys) and intestinal gastric carcinoma (IGC)were 12.2 %, 16.7 %, 7.1%, 22.6 %, 47.8 %, 46.9 % and60.8 %, respectively. A significant difference among typeⅢ IM and SG, SAG, type I and Ⅱ IM was found (P＜0.01),the difference between type Ⅲ and Dys, IGC being notsignificant.CONCLUSION: As a new tumor-related gene, expression of1A6 may be an effective parameter to predict the malignanttransformation of precancerous lesion to gastric carcinoma.
AIM:To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma. METHODS:One hundred and thirty-six cases of intestinal metaplasia(IM)from surgical resections and biopsy were classified by mucous staining.Expression of 1A6 in all cases was detected using immunohistochemical S-P method. RESULTS:The positive rates of 1A6 in normal and superficial gastritis(SG),severe atrophic gastritis(SAG),type Ⅰ,Ⅱ,Ⅲ IM,dysplasia(Dys)and intestinal gastric carcinoma(IGC) were 12.2 %,16.7 %,7.1%,22.6 %,47.8 %,46.9 % and 60.8 %,respectively.A significant difference among type Ⅲ IM and SG,SAG,type Ⅰ and Ⅱ IM was found(P<0.01), the difference between type Ⅲ and Dys,IGC being not significant. CONCLUSION:As a new tumor-related gene,expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
基金
National Key Fundamental Research 973 Project, No 1998051203
National High Technology Research and Development Program of China(863 Program),No2001AA221121
