摘要
目的 比较ITP(异环磷酰胺 +吡喃阿霉素 +顺铂 )与NP(去甲长春花碱 +顺铂 )方案治疗晚期非小细胞肺癌的临床有效率和毒副作用。方法 10 0例不能手术或术后复发转移的Ⅲ～Ⅳ期NSCLC患者随机分组 ,接受ITP或NP方案化疗 2～ 3个周期后评价疗效。结果 ①ITP组有效率为 5 1.1%,部分缓解率为46.8%;NP组有效率为 5 0 .9%,部分缓解率为 49.1%,两组近期疗效比较无显著性差异 (P >0 .0 5 )。②ITP组Ⅲ～Ⅳ度白细胞下降 2 8例 ( 5 9.6%) ,NP组 2 0例 ( 3 7.7%) ,两组比较有显著性差异 (P <0 .0 5 ) ;Ⅲ～Ⅳ度消化道反应ITP组 10例 ( 2 1.3 %) ,NP组 12例 ( 2 2 .6%) ,两组比较无显著性差异 (P >0 .0 5 )。结论 ITP和NP方案是治疗晚期NSCLC较有效的方案。与ITP方案相比 。
Objective To evaluate the efficacy and toxicity of ITP (ifosfamide + perarubicin + cisplatin) and NP (vinorelbine + cisplatin) regimens in the treatment of advanced non small cell lung cancer (NSCLC). Methods One hundred inoperatable or recurrent patients with stage Ⅲ and Ⅳ NSCLC were randomized into ITP group and NP group treated by the two regimens responsively for 2 or 3 cycles. Results The overall response rate was 51.5% for ITP group and 50.9% for the NP group, respectively. There was no statistically significant difference of the overall response rate between the two groups ( P >0.05). The major side effects were leukopenia and gastrointestinal reaction. The leukopenia incidence was higher in ITP group than that in NC group ( P <0.05). Conclusion Both ITP and NP regimens are effective for the advanced NSCLC. Compared with ITP regimen, NP regimen has less bone marrow toxicity than ITP regimen.
出处
《中国肺癌杂志》
CAS
2004年第1期64-66,共3页
Chinese Journal of Lung Cancer
