摘要
目的研究奥沙利铂和顺铂在治疗晚期非小细胞肺癌疗效和毒性反应的差异。方法晚期非小细胞肺癌患者109例随机分成2组，奥沙利铂加长春瑞宾组（奥铂组）56例，顺铂加长春瑞宾组（顺铂组）53例，两组每例患者至少完成两周期化疗再评价。结果两组所有的患者都完成两周期以上的化疗，奥铂组总有效率41．1％，顺铂组总有效率45．3％，两组比较差异无显著性（P〉0．05）；两组比较白细胞下降、血小板下降、血红蛋白下降、肾毒性差异均无显著性（均P〉0．05）；奥铂组恶心、呕吐发生低于顺铂组，奥铂组神经毒性明显高于顺铂组，而且比较差异有显著性（P〈0．05）。结论奥沙利铂加长春瑞宾和顺铂加长春瑞宾都是治疗晚期非小细胞肺癌的有效方案，两者疗效相似，区别是奥沙利铂加长春瑞宾神经毒性高于顺铂加长春瑞宾，消化道反应低于顺铂加长春瑞宾。
Objective To study therapeutic effect and toxic effect of oxaliplatin and cisplatin combined rigimen for advanced non-small cell lung cancer { NSCLC ）. Methods 109 cases of NSCLC were divided into two groups ： Oxaliplatin plus vinorelbine （Oxaliplatin group, n = 56 ） and cisplatin plus vinorelbine （ cisplatin group, n = 53）. Each patient was evaluated after at least two cycles of chemotherapy were completed. Results The total respouse rate （RR） was 41. i% in Oxaliplatin group and 45.3% in cisplatin group,with no significant difference（ P 〉 0.05） .There was no significant difference in the decrease of leukocyte count , platelet and hemoglobin as well as renal toxicity （ P 〉 0.05 for each）. Less patients of oxaliplatin group developed nausea and vomiting than the patients of cisplatin group and nerve toxicity was stronger in oxaliplatin group than in cisplatin group（ P 〈 0.05 ）. Conclusion Both Oxaliplatin plus vinorelbine and cisplatin plus vinorelbine are similarly effective in treating advanced nonsmall cell lung cancer,but the nerve toxicity of oxaliplatin plus vinorelbine is stronger than that of cisplatin plus vinorelbine and digestive tract response is lower than that of cisplatin plus vinorelbine.
出处
《中国医药》
2007年第1期42-43,共2页
China Medicine
关键词
非小细胞肺癌
奥沙利铂
顺铂
长春瑞宾
Non-small cell lung cancer
Oxaliplatin
Cisplatin
Vinorelbine
