摘要
目的:探究前列泰联合坦洛新治疗慢性前列腺炎临床观察及对前列腺组织中细胞因子的影响。方法:慢性前列腺炎患者89例,按照数字表法将其分为对照组44例和观察组45例。对照组采用坦洛新治疗,观察组采用前列泰联合坦洛新治疗,对比分析两组患者的临床治疗效果,NIH-CPSI评分,前列腺液中的白细胞、PH及sIgA水平,尿动力学指标,勃起功能指数表评分及不良反应情况。结果:观察组患者治疗后的总有效率(91.11%)、最大尿流率(17.27±2.69)mL/s及勃起功能评分(14.96±4.75)明显高于对照组的总有效率(72.73%)、最大尿流率(15.51±2.37)mL/s及勃起功能评分(12.93±4.14)。疼痛症状评分(6.47±1.72)、排尿症状评分(2.75±0.67)、生活质量评分(3.56±1.85)、白细胞计数(14.82±3.23)×10~9/L、PH(6.39±0.23)、sIgA水平(63.57±19.75)g/L、残尿量(6.21±2.73)mL明显低于对照组的疼痛症状评分(8.32±1.87)、排尿症状评分(3.52±0.81)、生活质量评分(5.13±1.14)、白细胞计数(17.73±3.75)×10~9/L、PH(6.73±0.25)、sIgA水平(104.02±21.91)g/L、残尿量(10.45±2.81)mL,差异有统计学意义(P<0.05)。两组患者治疗后不良反应情况相比,差异无统计学意义(P>0.05)。结论:前列泰联合坦洛新治疗慢性前列腺炎的临床治疗效果显著,患者临床上前列腺部位疼痛不适及排尿困难等症状得到有效减轻,尿动力学指标的恢复明显,患者前列腺液中的白细胞计数、pH值、sIgA水平降低,生活质量得到较大提高,用药不良反应发生率较低。
Objective:To explore the clinical effect of prostaglandin combined with tamsulosin on chronic prostatitis and its effect on cytokines in prostate tissue.Methods:Eighty-nine patients with chronic prostatitis were divided into 44 cases in the control group and 45 in the observation group according to the digital table method.The control group was treated with tamsulosin and the observation group was treated with prostaglandin combined with tamsulosin.The clinical treatment effect of the two groups,the NIH-CPSI score,the leukocyte,pH and sIgA levels in the prostatic fluid,the urodynamic index,the erectile function index score and the adverse reaction were compared.Results:The total effective rate(91.11%),the maximum urinary flow rate(17.27±2.69)mL/s and the erectile function score(14.96±4.75)in the observation group were significantly higher than the control group’s total effective rate(72.73%),maximum urinary flow rate(15.51±2.37)mL/s and erectile function score(12.93±4.14)and the pain symptom score(6.47±1.72).The pain symptom score(6.47±1.72),urination symptom score(2.75±0.67),quality of life score(3.56±1.85),white blood cell count(14.82±3.23)×10~9/L,pH(6.39±0.23),sIgA(63.57±19.75)g/L and residual urine volume(6.21±2.73)mL were significantly lower than those of the control group[the urinary symptom score(3.52±0.81),quality of life(5.13±1.14),white blood cell count(17.73±3.75)×10~9/L,PH(6.73±0.25),sIgA(104.02±21.91)g/L and residual urine volume(10.45±2.81)mL](P<0.05).There was no significant difference in adverse reactions after treatment between the two groups(P>0.05).Conclusion:The clinical therapeutic effect of prostaglandin combined with tamsulosin in the treatment of chronic prostatitis is significant.The symptoms of pain and dysuria in the prostate are effectively relieved and the recovery of urodynamic indexes is obvious.The leukocyte count,pH value,sIgA level in the prostatic fluid and the quality of life are obtained.The incidence of adverse drug reactions was lower.
作者
杨庆
胡洋
吴海啸
张恒
YANG Qing;HU Yang;WU Haixiao;ZHANG Heng(Department of Urology,Jinhua Center Hospital,Jinhua 321000,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第6期1433-1436,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2013AZ221)
