摘要
目的:探讨充血性心力衰竭(CHF)患者心气、阳虚证与肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及白细胞介素-10(IL-10)的关系。方法:选取CHF心气、阳虚证住院患者67名,分别进行NYHA心功能分级,并行心脏多普勒、血清TNF-α、IL-1β及IL-10等检查。结果:心气虚证组患者心功能分级以舒张功能不全和心功能Ⅰ级、Ⅱ级为多,心阳虚证组患者以心功能Ⅲ级、Ⅳ级为多(Ridit分析,P<0.01);心气虚证组患者E/A值、EF值高于心阳虚证组(P<0.01);心阳虚证组患者血清TNF-α、IL-1β水平高于心气虚证组(P<0.01或P<0.05);心阳虚证组患者血清IL-10水平低于心气虚证组(P<0.01)。结论:TNF-α、IL-1β与IL-10可能在CHF心气虚证向心阳虚证发展过程中起重要的作用,可以作为心气虚证、心阳虚证微观辨证的指标。
Objective: To investigate the relationship between the content of TNF-α, IL-1βor IL-10 and heart Qi deficiency syndrome or heart Yang deficiency syndrome of congestive heart failure (CHF). Methods: Sixty-seven patients of CHF were selected and divided into the heart Qi deficiency syndrome group and the heart Yang deficiency syndrome group according to the standard established by Senile Disease Committee in Zhengzhou city. Then the grade of heart failure was assessed according to NYHA. The heart of all patients was detected by dopler and the content of TNF-α, IL-1βand IL-10 in their sera were measured. Results: The heart failure grade of patients in the heart Qi deficiency syndrome group was GradeⅠor Grade Ⅱ, while that in the heart Yang deficiency syndrome group was Grade Ⅲ or Grade Ⅳ with very significant difference with the former (P<0.01). The value of E/A and EF of the heart Qi deficiency syndrome group was higher than that of the heart Yang deficiency syndrome group, and the result was quite opposite about the content of TNF-αand IL-1β (P<0.01 or P<0.05), and same as the content of IL-10 (P <0.01). Conclusion: TNF-α, IL-1βand IL-10 play a very important role during the development from heart Qi deficiency to heart Yang deficiency, and perhaps they can be used as indexes for the micro-bianzheng.
出处
《中国中医药信息杂志》
CAS
CSCD
2003年第8期14-16,共3页
Chinese Journal of Information on Traditional Chinese Medicine
